Targeted delivery of therapeutic agents to hepatocytes is a particularly attractive strategy for
the treatment of hepatocellular carcinoma and other liver diseases. The asialoglycoprotein …

A compact and stable bicyclic bridged ketal was developed as a ligand for the
asialoglycoprotein receptor (ASGPR). This compound showed excellent ligand efficiency …

The abundant cell surface asialoglycoprotein receptor (ASGPR) is a highly selective
receptor found on hepatocytes that potentially can be exploited as a selective shuttle for …

A series of novel, fluorescent ligands designed to bind with high affinity and specificity to the
asialoglycoprotein receptor (ASGP-R) has been synthesized and tested on human liver …

Hepatocyte resident afflictions continue to affect the human population unabated. The
asialoglycoprotein receptor (ASGPR) is primarily expressed on hepatocytes and minimally …

Background: Hepatocellular carcinoma (HCC) seriously affects human health, especially, it
easily develops multi-drug resistance (MDR) which results in treatment failure. There is an …

In vivogene therapy shows promise as a treatment for both genetic and acquired disorders.
The hepatic asialoglycoprotein receptor (ASGPr) binds asialoorosomucoid—polylysine …

The hepatocyte-specific asialoglycoprotein receptor (ASGPR) is an ideal candidate for
targeted drug delivery to the liver due to its high capacity for substrate clearance from …

Introduction 3. Asialoglycoprotein receptor 3.1. Biology of asialoglycoprotein receptor (ASGP-
R) 3.2. Carbohydrate recognition domain (CRD) 3.3 Internalization of the ligands by ASGP …

The asialoglycoprotein receptor (ASGPR) is a high-capacity galactose-binding receptor
expressed on hepatocytes that binds its native substrates with low affinity. More potent …