Mitochondria are critical organelles responsible for regulating the metabolic status of
skeletal muscle. These organelles exhibit remarkable plasticity by adapting their volume …

Skeletal muscle is a tissue with a low mitochondrial content under basal conditions, but it is
responsive to acute increases in contractile activity patterns (ie exercise) which initiate the …

Mitochondria are negatively affected by ageing leading to their inability to adapt to higher
levels of oxidative stress and this ultimately contributes to the systemic loss of muscle mass …

Loss of muscle mass and force occurs in many diseases such as disuse/inactivity, diabetes,
cancer, renal, and cardiac failure and in aging-sarcopenia. In these catabolic conditions the …

Mitochondrial health is an important mediator of cellular function across a range of tissues,
and as a result contributes to whole‐body vitality in health and disease. Our understanding …

Background Maintaining skeletal muscle mitochondrial content and function is important for
sustained health throughout the lifespan. Exercise stimulates important key stress signals …

Mitochondria are the hub for energy production within living cells. They can undergo
morphological changes in response to nutrient availability and cellular stress. Here, we …

Decline in human muscle mass and strength (sarcopenia) is a hallmark of the aging
process. A growing body of research in the areas of bioenergetics and protein turnover has …

Aging is associated with mitochondrial dysfunction, which leads to a decline in cellular
function and the development of age-related diseases. Reduced skeletal muscle mass with …

Mitochondria are characterized by its pivotal roles in managing energy production, reactive
oxygen species, and calcium, whose aging‐related structural and functional deteriorations …