Discovering that the anesthetic drug ketamine has rapidly acting antidepressant effects in
many individuals with major depression is one of the most important findings in clinical …

Major depression is a stress-linked disease with significant morbidity and the anesthetic
drug ketamine is of growing interest in the treatment of depression, since in responsive …

Ketamine, a dissociative anesthetic agent, appears to have rapid antidepressant effects at
sub-anesthetic doses in clinically depressed patients. Although promising, these results …

One of the most striking discoveries in the treatment of major depression was the finding that
infusion of a single sub-anesthetic dose of ketamine induces rapid and sustained …

The anesthetic drug ketamine has been successfully repurposed as an antidepressant in
human subjects. This represents a breakthrough for clinical psychopharmacology, because …

Over the last two decades, the dissociative anaesthetic agent ketamine, an uncompetitive N-
Methyl-D-Aspartate (NMDA) receptor antagonist, has emerged as a novel therapy for …

A decade has now passed since research into the antidepressant effects of ketamine began
in earnest, after the clinical trial reported by Zarate et al. in 2006 (1). In that proof-of-concept …

Over the past 50 years, ketamine has solidified its position in both human and veterinary
medicine as an important anesthetic with many uses. More recently, ketamine has been …

Depression, the most prevalent psychiatric disorder, is characterized by increased negative
affect (ie depressed mood) and reduced positive affect (ie anhedonia). Stress is a risk factor …

Numerous randomized double-blind clinical trials have consistently shown that that a single
intravenous administration of a subanesthetic dose of ketamine to treatment-resistant …