Advanced fed-batch microbioreactors mitigate scale up risks and more closely mimic
industrial cultivation practices. Recently, high throughput microscale feeding strategies have …

To verify the reproducibility of cultivations of Escherichia coli in novel millilitre‐scale
bioreactors, fully automated fed‐batch cultivation was performed in seven parallel‐operated …

Abstract Systems metabolic engineering faces the formidable task of rewiring microbial
metabolism to cost-effectively generate high-value molecules from a variety of inexpensive …

The acceleration of bioprocess development for biologics and vaccines can be enabled by
automated high throughput technologies. This will alleviate the significant resource burden …

This review provides a broad overview of recent patents and developments in the field of
small scale bioreactors. The scope of the work will focus on vessels from about 500 ml down …

Background Fed-batch conditions are advantageous for industrial cultivations as they avoid
unfavorable phenomena appearing in batch cultivations. Those are for example the …

Advances in high‐throughput process development and optimization involve the rational
use of miniaturized stirred bioreactors, instrumented shaken flasks and microtiter plates. As …

In recent years, microbioreactor (MBR) systems have evolved towards versatile bioprocess
engineering tools. They provide a unique solution to combine higher experimental …

Objectives Recombinant protein production processes in Escherichia coli are usually
operated in fed-batch mode; therefore, the elaboration of a fed-batch cultivation protocol in …

With modern genetic engineering tools, high number of potentially improved production
strains can be created in a short time. This results in a bottleneck in the succeeding step of …