Cancer patients' outcome and survival depends on the early diagnosis of malignant lesions.
Several investigation methods used for the prevention and early detection strategies have …

Both genetic and epigenetic events have been implicated in the stepwise histological
progression involving adenoma-carcinoma and hyperplastic polyp/serrated adenoma …

Silencing of gene expression by aberrant cytosine methylation is a prominent feature of
human tumors, including colorectal cancers. Epigenetic changes of this type play …

Colon cancers arise from benign neoplasms and evolve into adenocarcinomas through a
stepwise histological progression sequence, proceeding from either adenomas or …

Colorectal cancer (CRC) is one of most common malignancies and a leading cause of
cancer related deaths worldwide. Epigenetic change is an important mechanism of …

Background: Colorectal cancers are characterized by genetic and epigenetic alterations.
This study aimed to explore the timing of promoter methylation and relationship with …

Migheli F, Migliore L. Epigenetics of colorectal cancer. Colorectal cancer (CRC) develops
through a multistep process that results from the progressive accumulation of mutations and …

Malignant transformation is now known to require a series of molecular alterations that
disrupt a limited number of pathways including autocrine and paracrine responses to growth …

Colorectal cancer has provided an excellent model for studying the genetic basis of cancer
and is one of the better‐understood malignancies in this regard. The orderly progression of …

The aberrant methylation of CpG islands is a common epigenetic alteration found in
cancers. The process contributes to cancer formation through the transcriptional silencing of …