BACKGROUND: Nonmetastatic T4b colon cancer has been traditionally treated with upfront
surgery, often requiring technically challenging multiorgan resection. Neoadjuvant …

Abstract Background In 2016, the National Comprehensive Cancer Network included
neoadjuvant chemotherapy as a treatment option for patients with clinical T4b colon cancer …

METHODS: The National Cancer Database (NCDB) was queried for patients with cT4bM0
colon cancer (2006–2016). Patients treated with NT were propensity-score matched to those …

Background/Aim: The efficacy of neoadjuvant chemotherapy (NAC) for colon cancer remains
unestablished. This study aimed to investigate the outcomes of NAC in patients with locally …

Background Despite persistently poor oncological outcomes, approaches to the
management of T4 colonic cancer remain variable, with the role of neoadjuvant therapy …

Introduction: Neoadjuvant chemotherapy (CT) for locally advanced colon cancer (LACC)
could potentially lead to tumor shrinkage, eradication of micrometastases, and prevention of …

Aim Neoadjuvant chemotherapy (NCT) for nonmetastatic colon cancer is not routinely used,
and is currently only recommended as a treatment option for a subgroup of patients with T4b …

Background Resection of T4 colon cancer remains challenging compared to lower T stages.
Data on the effect of neoadjuvant radiation to improve resectability and survival are lacking …

While adjuvant treatment of colon cancers that penetrate the serosa (T4) have been well-
established, neoadjuvant strategies have yet to be formally evaluated. Our objective was to …

Objective: To evaluate the safety and efficacy of surgical treatment after neoadjuvant
chemotherapy (NCT) for patients with cT4N+ colon cancer, and to explore whether the …