Atopic dermatitis (AD) is a chronic inflammatory skin disease in humans. It was recently
noted that the characteristics of epidermal barrier functions critically influence the …

Tight junctions are important for skin barrier function. The tight junction protein claudin 1
(Cldn-1) has been reported to be down-regulated in nonlesional skin of atopic dermatitis …

The transmembrane protein claudin-1 is a major component of epidermal tight junctions
(TJs), which create a dynamic paracellular barrier in the epidermis. Claudin-1 …

BACKGROUND: Atopic dermatitis (AD) is characterized by dry skin and a hyperactive
immune response to allergens, 2 cardinal features that are caused in part by epidermal …

The transfer of sweat to the skin surface without leakage is important for the homeostatic
regulation of skin and is impaired in atopic dermatitis. Although the precise composition of …

Abstract Background Tight junctions (TJs) have important roles in skin barrier function. The
TJ protein claudin-1 (CLDN1) is decreased in atopic dermatitis (AD). However, little is known …

BACKGROUND: Tight junctions (TJs) contribute to the epithelial barrier function by
preventing leakage of solutes through the intercellular space. In the skin, TJs occur in the …

Tight junction (TJ) dysfunction in the stratum granulosum leads to aberrant barrier function of
the stratum corneum (SC) in the epidermis. However, it is unclear whether TJs are perturbed …

Background The strong association between epidermal barrier gene variants and Atopic
Dermatitis (AD) highlights that impaired skin barrier is a key feature in the pathogenesis of …

The tight junction (TJ) and its adhesion molecules, claudins, are responsible for the barrier
function of simple epithelia, but TJs have not been thought to play an important role in the …