Single-cell RT-PCR was used to sample CD19+ B cell repertoires in cerebrospinal fluid
(CSF) of patients with multiple sclerosis (MS) or viral meningitis. Analysis of amplified Ab H …

Multiple sclerosis (MS) lesions in the CNS are characterized by disseminated demyelination
with perivascular infiltrates of macrophages, T cells, and B cells. To investigate the origin …

The accumulation of B lymphocyte clones in the cerebrospinal fluid (CSF) of patients with
multiple sclerosis (MS) and patients with other neurological disorders was investigated …

In the central nervous system of patients with multiple sclerosis, B cell aggregates populate
the meninges, raising the central question as to whether these structures relate to the B cell …

Previous findings from our laboratory demonstrated that some clonally expanded
cerebrospinal fluid (CSF) B cells from MS patients exhibit diminished mutation targeting …

Clonally expanded populations of B cells carrying somatic mutations of Ig variable (V) region
genes have been detected in the CNS of subjects with multiple sclerosis (MS), suggesting …

Increased amounts of intrathecally synthesized IgG and oligoclonal bands have long been
recognized as a hallmark of multiple sclerosis (MS). B cells and plasma cells are …

Purpose: to determine whether cerebrospinal fluid (CSF) B cells exhibit clonal expansion in
patients recently diagnosed with multiple sclerosis (MS). CSF B cell clonal expansion was …

We re-engineered the immunoglobulin rearrangements from clonally expanded CSF B cells
of three Multiple Sclerosis patients as Fab fragments, and used three methods to test for their …

The cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients is characterized by
increased concentrations of immunoglobulin (Ig), which on electrophoretic analysis shows …