A series of biologically active novel Mannich bases containing with a 1 H-1, 2, 4-triazole-5-
one ring were developed to evaluate the cytotoxic activity. For this purpose, the synthesized …

Three new functionalized 4-aminopyrazole derivatives were synthesized and cyclized with
phenyl isothiocyanate to yield the corresponding three pyrazolo [4, 3-d] pyrimidine …

Abstract Targeting Hec1/Nek2 is considered as crucial target for cancer treatment due to its
significant role in cell proliferation. In pursuit of this, a series of twenty-five 2-aminothiazoles …

Abstracts This work used quantum chemical method via DFT to calculate molecular
descriptors for the development of QSAR model to predict bioactivity (IC 50-50% inhibition …

Azetidine substituent group has a wide range of application in organic chemistry and
medical field. In this study, a novel azetidine derivative and its reaction mechanism has been …

Molecular docking simulation of seven (7) compounds of 2, 5-Disubstituted-1, 3, 4-
Oxadiazole was carried out so as to evaluate their theoretical binding affinities, targeting …

Breast cancer (BC) is a global health concern and the leading cause of cancerous death
among women across the world, BC has been characterized by fresh lump in the breast or …

In this study, we researched the reactions of 5-(5-bromofuran-2-yl)-4-methyl-1, 2, 4-triazole-3-
thiol and 5-thiophene-(3-ylmethyl)-4R-1, 2, 4-triazole-3-thiols with some halogen-containing …

Breast cancer is the most frequent female cancer and second cause of cancer-related
deaths among women around the world. Two thirds of breast cancer patients have hormone …

Cancer is one of the greatest challenges in modern medicine today. Difficult and long-term
treatment, the many side effects of the drugs used and the growing resistance to treatment of …