Both genetic and epigenetic mechanisms intimately regulate cancer development and
chemoresistance. Different genetic alterations are observed in multiple genes, and most are …

ABSTRACT c-myc is one of a small family of proto-oncogenes that do not require mutation to
contribute to neoplastic transformation. Instead, the deregulated expression of the …

MYC is a proto-oncogene regulating a large number of genes involved in a plethora of
cellular functions. Its deregulation results in activation of MYC gene expression and/or an …

CMYC has long been known to be among the most frequently de-regulated oncogenes in
human cancer. Only recently, however has a clear understanding begun to emerge of how it …

The proto-oncogene c-myc has been the subject of intensive research since its discovery. It
is already known that this oncogene targets multiple pathways for the initiation and …

The universal deregulation of c-myc gene expression in tumor cells suggests that this
oncogene represents an attractive target for cancer therapeutic purposes. The same applies …

MYC overexpression has been implicated in the pathogenesis of most types of human
cancers. MYC is likely to contribute to tumorigenesis by its effects on global gene …

The c-myc oncogene acts as a pluripotent modulator of transcription during normal cell
growth and proliferation. Deregulated c-myc activity in cancer can lead to excessive …

Deregulated expression of c-MYC occurs in a broad range of human cancers and is often
associated with poor prognosis, indicating a key role for this oncogene in tumour …

c-Myc is frequently deregulated in human cancers. The c-Myc oncoprotein is a transcription
factor, with many of its target genes encoding proteins that initiate and maintain the …