Introduction: More than 50 mutations in the MAPT gene result in heterogeneous forms of
frontotemporal lobar dementia with tau inclusions (FTLD-Tau). However, early pathogenic …

Mutations in the MAPT gene encoding tau protein can cause autosomal dominant
neurodegenerative tauopathies including frontotemporal dementia (often with …

Frontotemporal lobar degeneration with MAPT pathogenic variants (FTLD-MAPT) has
heterogeneous tau pathological inclusions postmortem, consisting of three-repeat (3R) or …

Mutations in the gene MAPT encoding tau, a microtubules-associated protein, cause a
subtype of familial neurodegenerative disorder, known as frontotemporal lobar degeneration …

Mutations in MAPT (microtubule-associated protein tau) cause frontotemporal dementia
(FTD). MAPT mutations are associated with abnormal tau phosphorylation levels and …

The neuronal microtubule-associated protein tau, MAPT, is central to the pathogenesis of
many dementias. Autosomal-dominant mutations in MAPT cause inherited frontotemporal …

Tau aggregation is a hallmark of several neurodegenerative diseases, including Alzheimer's
disease and frontotemporal dementia. There are disease-causing variants of the tau …

Abstract See Josephs (doi: 10.1093/brain/awx367) for a scientific commentary on this article.
In many neurodegenerative disorders, familial forms have provided important insights into …

Tau protein is a microtubule-associated protein encoded by the MAPT gene that carries out
a myriad of physiological functions and has been linked to certain pathologies collectively …

Tauopathies such as frontotemporal dementia (FTD) remain incurable to date, partially due
to the lack of translational in vitro disease models. The MAPT gene, encoding the …