The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, creates an urgent
need for identifying molecular mechanisms that mediate viral entry, propagation, and tissue …

Abstract Angiotensin-converting enzyme 2 (ACE2) and accessory proteases (TMPRSS2 and
CTSL) are needed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

There is pressing urgency to understand the pathogenesis of the severe acute respiratory
syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS …

Abstract The SARS-CoV-2 coronavirus, the etiologic agent responsible for COVID-19
coronavirus disease, is a global threat. To better understand viral tropism, we assessed the …

A deficient interferon (IFN) response to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection has been implicated as a determinant of severe coronavirus …

There are currently limited Food and Drug Administration (FDA)-approved drugs and
vaccines for the treatment or prevention of Coronavirus Disease 2019 (COVID-19) …

The SARS-CoV-2 pandemic affecting the human respiratory system severely challenges
public health and urgently demands for increasing our understanding of COVID-19 …

To better understand host-virus genetic dependencies and find potential therapeutic targets
for COVID-19, we performed a genome-scale CRISPR loss-of-function screen to identify …

Novel coronavirus disease 2019 (COVID-19) severity is highly variable, with pediatric
patients typically experiencing less severe infection than adults and especially the elderly …

Early stages of deadly respiratory diseases including COVID-19 are challenging to elucidate
in humans. Here, we define cellular tropism and transcriptomic effects of SARS-CoV-2 virus …