Female breast cancer represents 15.2% of all new cancer cases in the United States with an
estimated 297,790 new cases and 43,170 deaths in 2023 [1]. Based on data collated by the …

Female breast cancer accounts for 15.2% of all new cancer cases in the United States, with
a continuing increase in incidence despite efforts to discover new targeted therapies. With …

Adipocytes are the predominant cell population in the normal breast and while recent
attention has pointed to adipocyte-tumor cell crosstalk as a driver of breast cancer biology …

The role of the adipocyte in the tumor microenvironment has received significant attention as
a critical mediator of the obesity-cancer relationship. Current estimates indicate that 650 …

Background: Extreme adiposity has been associated with tumor progression and increased
mortality after a breast cancer diagnosis, but the underlying mechanisms remain unclear …

Breast cancer, especially triple negative breast cancer, impacts a large proportion of the
female population. Approximately ten to fifteen percent of all breast cancer diagnoses will be …

Growing evidence indicates that adiposity is associated with raised cancer incidence,
morbidity and mortality. In a subset of tumors, cancer cell growth and/or metastasis …

Breast cancer metastasis is a major cause of mortality in women with cancer, and the role of
the breast microenvironment in this process is significant. Adipocytes within breast adipose …

Primary human breast cancers invade surrounding fat and contact adipocytes, inflammatory
infiltrates, and fibrous stroma. This tissue niche influences breast tumor progression. Here …

Recent preclinical and clinical data accumulate evidence indicating that obesity may worsen
the incidence, severity, and mortality of many types of cancer, including breast cancer. In the …