Innovative strategies to improve the clinical application of NK cell-based immunotherapy

M Tarannum, R Romee, RM Shapiro - Frontiers in Immunology, 2022 - frontiersin.org
Natural killer cells constitute a part of the innate immune system that mediates an effective
immune response towards virus-infected and malignant cells. In recent years, research has …

Next generation immuno-oncology strategies: unleashing NK cells activity

A Mendoza-Valderrey, M Alvarez, A De Maria… - Cells, 2022 - mdpi.com
In recent years, immunotherapy has become a powerful therapeutic option against multiple
malignancies. The unique capacity of natural killer (NK) cells to attack cancer cells without …

NK cell-based cancer immunotherapy: from basic biology to clinical development

S Liu, V Galat, Y Galat4, YKA Lee… - Journal of hematology & …, 2021 - Springer
Natural killer (NK) cell is a specialized immune effector cell type that plays a critical role in
immune activation against abnormal cells. Different from events required for T cell activation …

Natural killer cells: the linchpin for successful cancer immunotherapy

KA Shaver, TJ Croom-Perez, AJ Copik - Frontiers in immunology, 2021 - frontiersin.org
Cancer immunotherapy is a highly successful and rapidly evolving treatment modality that
works by augmenting the body's own immune system. While various immune stimulation …

Next generation natural killer cells for cancer immunotherapy

F Rossi, N Fredericks, A Snowden… - Frontiers in …, 2022 - frontiersin.org
In recent years, immunotherapy for cancer has become mainstream with several products
now authorized for therapeutic use in the clinic and are becoming the standard of care for …

Natural killer cell-based therapies targeting cancer: possible strategies to gain and sustain anti-tumor activity

CIM Dahlberg, D Sarhan, M Chrobok, AD Duru… - Frontiers in …, 2015 - frontiersin.org
Natural killer (NK) cells were discovered 40 years ago, by their ability to recognize and kill
tumor cells without the requirement of prior antigen exposure. Since then, NK cells have …

Exploring the NK cell platform for cancer immunotherapy

JA Myers, JS Miller - Nature reviews Clinical oncology, 2021 - nature.com
Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system that are
capable of killing virally infected and/or cancerous cells. Nearly 20 years ago, NK cell …

Harnessing natural killer cell antitumor immunity: from the bench to bedside

KV Woan, JS Miller - Cancer immunology research, 2019 - AACR
Natural killer (NK) cells are critical effector lymphocytes mediating tumor immune
surveillance and clearance. They do so by direct tumor killing using cytolytic granules and …

Bringing natural killer cells to the clinic: ex vivo manipulation

RW Childs, M Berg - Hematology 2013, the American Society …, 2013 - ashpublications.org
Recently, there has been a substantial gain in our understanding of the role that natural
killer (NK) cells play in mediating innate host immune responses against viruses and cancer …

Challenges of NK cell-based immunotherapy in the new era

F Fang, W Xiao, Z Tian - Frontiers of Medicine, 2018 - Springer
Natural killer cells (NKs) have a great potential for cancer immunotherapy because they can
rapidly and directly kill transformed cells in the absence of antigen presensitization. Various …