Hyperinsulinemia, hyperglycemia, and chronic inflammation may play a role in
hepatocellular carcinoma (HCC). Treatment of HCC patients with the antidiabetic medication …

Nonalcoholic fatty liver disease (NAFLD) is strongly linked to the global epidemic of obesity
and type 2 diabetes mellitus (T2DM). Notably, NAFLD can progress from the mildest form of …

The tumor microenvironment (TME) plays a pivotal role in the fate of cancer cells, and tumor-
infiltrating immune cells have emerged as key players in shaping this complex milieu …

Epidemiological, preclinical and cellular studies in the last 5 years have shown that
metformin exerts anti‐tumoral properties, but its mode of action in cancer remains unclear …

Metformin, an anti-hyperglycemic drug, has been known to have antitumor properties for
around 15 years. Although there are a number of reports attributing the antitumor function of …

Simple Summary The study investigates the potential use of metformin, a medication
commonly prescribed for type 2 diabetes, in the treatment of hepatocellular carcinoma …

Metformin has been known to treat type 2 diabetes for decades and is widely prescribed
antidiabetic drug. Recently, its anticancer potential has also been discovered. Moreover …

This study seeks to test the effect of metformin treatment on the outcomes of breast cancer in
BALB/c mice bearing 4 T1 breast cancer cells. The survival rate and tumor size of mice were …

Stimulating antitumor immunity is an attractive idea for suppressing tumors. CD4+ and CD8+
T cells as well as natural killer cells (NK) are the primary antitumor immune cells in the tumor …

The immune system plays an essential and central role in tumor cell differentiation,
proliferation, angiogenesis, apoptosis, invasion, and metastasis. Over the past decade …