Ferroptosis requires not only the accumulation of iron ions, but also changes in many
ferroptosis-related regulators, including a decrease in GPX4 and inhibition of SLC7A11 for …

Ferroptosis is a multistep regulated cell death process induced by iron accumulation and
lipid peroxidation. Classical GPX4‐dependent pathway and GPX4‐independent pathways …

Metabolic syndrome is a medical condition characterized by several metabolic disorders in
the body. Long-term metabolic disorders raise the risk of cardiovascular disease (CVD) and …

Dysregulation in iron metabolism is associated with obesity, type 2 diabetes, and other
metabolic diseases, whereas the underlying mechanisms of imbalanced glycolipid …

Obesity is widely recognized as a major global health problem caused by a chronic energy
imbalance resulting from a combination of excess caloric intake and insufficient energy …

Ferroptosis is an iron-dependent form of cell death characterized by an accumulation of lipid
peroxides. A growing body of recent evidence supports the notion that ferroptosis plays an …

Regulation of cell mortality for disease treatment has been the focus of research. Ferroptosis
is an iron-dependent regulated cell death whose mechanism has been extensively studied …

The annual incidence of metabolic diseases such as diabetes, non-alcoholic fatty liver
disease (NAFLD), osteoporosis, and atherosclerosis (AS) is increasing, resulting in a heavy …

Systemic lupus erythematosus (SLE), the most common form of lupus, is a chronic
autoimmune disorder characterized by a global loss of self-tolerance and hyper-activation of …

Background: Cell death is a fundamental biological phenomenon that contributes to the
pathogenesis of various diseases. Regulation of iron and iron metabolism has received …