Herein we trace links between biochemical pathways, pathogenesis, and metabolic
diseases to set the stage for new therapeutic advances. Cellular and acellular …

The role of mitochondrial function in health and disease has become increasingly
recognized, particularly in the last two decades. Mitochondrial dysfunction as well as …

Mitochondria are essential organelles for many aspects of cellular homeostasis, including
energy harvesting through oxidative phosphorylation. Alterations of mitochondrial function …

With the current explosion of knowledge on the role of mitochondrial dysfunction in the
genesis of various human disease states, there is an increased interest in targeting …

In the last decade, there has been an increased appreciation for mitochondria as central
hubs in diverse processes, such as cellular energy, immunity, and signal transduction. As …

Disruption of mitochondrial function is a common feature of inherited mitochondrial diseases
(mitochondriopathies) and many other infectious and non-infectious diseases including viral …

Mitochondria are the powerhouses of the cell and are involved in essential functions of the
cell, including ATP production, intracellular Ca 2+ regulation, reactive oxygen species …

Mitochondrial damage is implicated as a major contributing factor for a number of
noncommunicable chronic diseases such as cardiovascular diseases, cancer, obesity, and …

Mitochondria play a crucial role in cell life and death by regulating bioenergetic and
biosynthetic pathways. They are able to adapt rapidly to different microenvironmental …

Metabolic syndromes (MS) are a cluster of disorders such as obesity, hypertension,
dyslipidemia, and diabetes. Cardiometabolic syndrome (CMS), a branch of MS, is a group of …