Characteristics of the intrahepatic cytotoxic T lymphocyte response in chronic hepatitis C virus infection

MJ Koziel, BD Walker - Springer seminars in immunopathology, 1997 - Springer
Hepatitis C virus (HCV) infection remains a major cause of acute viral hepatitis worldwide,
resulting in significant morbidity and mortality due to the development of chronic hepatitis in …

The presence of an intrahepatic cytotoxic T lymphocyte response is associated with low viral load in patients with chronic hepatitis C virus infection

AJ Freeman, Y Pan, CE Harvey, JJ Post, MG Law… - Journal of …, 2003 - Elsevier
Background/Aims: The role of cytotoxic T lymphocytes (CTL) in limiting viral replication and
producing hepatocellular injury in patients with chronic hepatitis C virus (HCV) infection is …

Vigorous peripheral blood cytotoxic T cell response during the acute phase of hepatitis C virus infection

M Cucchiarini, AR Kammer, B Grabscheid… - Cellular …, 2000 - Elsevier
After infection by hepatitis C virus (HCV), a minority of patients develop acute symptomatic
disease and some of them are able to clear the virus. In this study, we analyzed peripheral …

Intrahepatic hepatitis C virus-specific cytotoxic T lymphocyte activity and response to interferon alfa therapy in chronic hepatitis C

DR Nelson, CG Marousis, T Ohno, GL Davis… - Hepatology, 1998 - journals.lww.com
Hepatitis C virus (HCV)-specific cytotoxic T lymphocytes (CTL) have been shown to play a
role in host defense and pathogenesis of chronic HCV infection. Our aim was to test the …

The role of hepatitis C virus-specific cytotoxic T lymphocytes in chronic hepatitis C.

DR Nelson, CG Marousis, GL Davis… - … (Baltimore, Md.: 1950 …, 1997 - journals.aai.org
Cellular immune responses, particularly those mediated by CD8+ CTL, may be important in
the pathogenesis and control of hepatitis C virus (HCV) infection. To define the role of HCV …

Quantitative analysis of the peripheral blood cytotoxic T lymphocyte response in patients with chronic hepatitis C virus infection.

B Rehermann, KM Chang… - The Journal of …, 1996 - Am Soc Clin Investig
Hepatitis C virus (HCV)-specific cytotoxic T lymphocytes (CTL) are present in the peripheral
blood and liver of chronically infected patients. The current study was performed to study the …

[PDF][PDF] Cytotoxic T lymphocyte response and viral load in hepatitis C virus infection

K Hiroishi, H Kita, M Kojima, H Okamoto… - …, 1997 - Wiley Online Library
Abstract A cytotoxic T lymphocyte (CTL) response to the hepatitis C virus (HCV)
nucleoprotein residues 88‐96 that are the minimal and optimal epitope for human leukocyte …

Differential cytotoxic T-lymphocyte responsiveness to the hepatitis B and C viruses in chronically infected patients

B Rehermann, KM Chang, J McHutchinson… - Journal of …, 1996 - Am Soc Microbiol
Cytotoxic T lymphocytes (CTL) are thought to control hepatitis B virus (HBV) infection, since
they are readily detectable in patients who clear the virus whereas they are hard to detect …

Immunopathology of hepatitis C

KM Chang, B Rehermann, FV Chisari - Springer seminars in …, 1997 - Springer
Hepatitis C virus (HCV) infection becomes persistent in the majority of instances in the face
of a Immoral and cellular immune response, and persistent HCV infection is associated with …

Hepatitis C virus-specific cytolytic T lymphocyte and T helper cell responses in seronegative persons

MJ Koziel, DKH Wong, D Dudley… - Journal of Infectious …, 1997 - academic.oup.com
Hepatitis C virus (HCV) is a common infection worldwide, and in most persons, it leads to
persistent viremia and liver damage. Efforts to identify the correlates of protective immunity …