Prolonged exposure of the brain to ethanol is a prerequisite for developing ethanol
dependence, but the underlying neural adaptations are unknown. Here we demonstrate that …

Background: Alcohol addiction develops through a series of stages, and mechanistic studies
are needed to understand the transition from initial drug use to sustained controlled alcohol …

Neuroadaptations that participate in the ontogeny of alcohol dependence are likely a result
of altered gene expression in various brain regions. The present study investigated brain …

Objective: Development of alcohol dependence is gradual, requires prolonged exposure to
alcohol and reflects neuroadaptive processes in the brain. An understanding of these …

Using a well-established model of ethanol dependence and relapse, this study examined
adaptations in glutamatergic transmission in the nucleus accumbens (NAc) and their role in …

The objective of this study was to determine the effects of binge-like alcohol drinking on
gene expression changes in the nucleus accumbens (ACB) of alcohol-preferring (P) rats …

Background: Ethanol addiction has been conceptualized as a progression from occasional,
impulsive use to compulsive behavior. Ethanol‐dependence is a chronic pathology with …

Chronic alcohol consumption and withdrawal leads to anxiety, escalated alcohol drinking
behavior, and alcohol dependence. Alterations in the function of key structures within the …

Background: Recent findings suggest that adenosine is involved in the neural and
behavioral effects of ethanol (EtOH). Studies in neural cell culture show that EtOH, via …

Alterations in gene expression are thought to help mediate certain effects of alcohol in the
brain. We have analyzed the expression of approximately 24,000 genes using …