Proliferating cells need to produce a large amount of energy and, at the same time, need to
maintain a constant supply of biosynthetic precursors of macromolecules that are used as …

The estrogen-related receptor α (ERRα) is an orphan member of the nuclear receptor
superfamily of transcription factors whose activity is regulated by the expression level and/or …

The critical role that altered cellular metabolism plays in promoting and maintaining the
cancer phenotype has received considerable attention in recent years. For many years it …

As coordinators of energy demands and nutritional supplies, the peroxisome proliferator-
activated receptor γ (PPARγ) coactivator 1 (PGC-1) family of transcriptional coactivators …

Deregulation of cellular metabolism is well established in cancer. The mitochondria are
dynamic organelles and act as the center stage for energy metabolism. Central to …

Cancer cells reprogram their metabolism using different strategies to meet energy and
anabolic demands to maintain growth and survival. Understanding the molecular and …

Peroxisome proliferator-activated receptor γ (PPARγ) coactivator 1α (PGC-1α) is a
transcriptional coactivator that is a key component in the regulation of energy production and …

Transcriptional control of cellular energy metabolic pathways is achieved by the coordinated
action of numerous transcription factors and associated coregulators. Several members of …

The PGC1 family (Peroxisome proliferator-activated receptor γ (PPARγ) coactivators) of
transcriptional coactivators are considered master regulators of mitochondrial biogenesis …

The mechanisms linking tumor microenvironment acidosis to disease progression are not
understood. Here, we used mammary, pancreatic, and colon cancer cells to show that …