Allosteric SHP2 inhibitors in cancer: Targeting the intersection of RAS, resistance, and the immune microenvironment
The nonreceptor protein tyrosine phosphatase SHP2 (encoded by PTPN11) integrates
growth and differentiation signals from receptor tyrosine kinases (RTKs) into the …
growth and differentiation signals from receptor tyrosine kinases (RTKs) into the …
Recent advances of SHP2 inhibitors in cancer therapy: current development and clinical application
X Yuan, H Bu, J Zhou, CY Yang… - Journal of medicinal …, 2020 - ACS Publications
SHP2 (Src homology-2 domain-containing protein tyrosine phosphatase-2) is a non-
receptor protein tyrosine phosphatase that removes tyrosine phosphorylation. Functionally …
receptor protein tyrosine phosphatase that removes tyrosine phosphorylation. Functionally …
[HTML][HTML] Strategies to overcome drug resistance using SHP2 inhibitors
M Liu, S Gao, RM Elhassan, X Hou, H Fang - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Encoded by PTPN11, the SHP2 (Src homology-2 domain-containing protein tyrosine
phosphatase-2) is widely recognized as a carcinogenic phosphatase. As a promising anti …
phosphatase-2) is widely recognized as a carcinogenic phosphatase. As a promising anti …
Allosteric inhibition of SHP2: identification of a potent, selective, and orally efficacious phosphatase inhibitor
J Garcia Fortanet, CHT Chen, YNP Chen… - Journal of medicinal …, 2016 - ACS Publications
SHP2 is a nonreceptor protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene
involved in cell growth and differentiation via the MAPK signaling pathway. SHP2 also …
involved in cell growth and differentiation via the MAPK signaling pathway. SHP2 also …
Identification of TNO155, an allosteric SHP2 inhibitor for the treatment of cancer
MJ LaMarche, M Acker, A Argintaru… - Journal of medicinal …, 2020 - ACS Publications
SHP2 is a nonreceptor protein tyrosine phosphatase encoded by the PTPN11 gene and is
involved in cell growth and differentiation via the MAPK signaling pathway. SHP2 also plays …
involved in cell growth and differentiation via the MAPK signaling pathway. SHP2 also plays …
Allosteric inhibitors of SHP2 with therapeutic potential for cancer treatment
SHP2, a cytoplasmic protein-tyrosine phosphatase encoded by the PTPN11 gene, is
involved in multiple cell signaling processes including Ras/MAPK and Hippo/YAP pathways …
involved in multiple cell signaling processes including Ras/MAPK and Hippo/YAP pathways …
Targeting SHP2 as a promising strategy for cancer immunotherapy
Q Liu, J Qu, M Zhao, Q Xu, Y Sun - Pharmacological research, 2020 - Elsevier
Src homology-2-containing protein tyrosine phosphatase 2 (SHP2) is a major phosphatase
involved in several cellular processes. In recent years, SHP2 has been the focus of …
involved in several cellular processes. In recent years, SHP2 has been the focus of …
Shp2: A pleiotropic target at the interface of cancer and its microenvironment
NM Sodir, G Pathria, JI Adamkewicz, EH Kelley… - Cancer discovery, 2023 - AACR
The protein phosphatase SHP2/PTPN11 has been reported to be a key modulator of
proliferative pathways in a wide range of malignancies. Intriguingly, SHP2 has also been …
proliferative pathways in a wide range of malignancies. Intriguingly, SHP2 has also been …
[HTML][HTML] Tyrosine phosphatase SHP2 inhibitors in tumor-targeted therapies
Src homology containing protein tyrosine phosphatase 2 (SHP2) represents a noteworthy
target for various diseases, serving as a well-known oncogenic phosphatase in cancers. As …
target for various diseases, serving as a well-known oncogenic phosphatase in cancers. As …
Optimization of fused bicyclic allosteric SHP2 inhibitors
JT Bagdanoff, Z Chen, M Acker, YN Chen… - Journal of medicinal …, 2019 - ACS Publications
SHP2 is a nonreceptor protein tyrosine phosphatase within the mitogen-activated protein
kinase (MAPK) pathway controlling cell growth, differentiation, and oncogenic …
kinase (MAPK) pathway controlling cell growth, differentiation, and oncogenic …
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