Allosteric SHP2 inhibitors in cancer: Targeting the intersection of RAS, resistance, and the immune microenvironment

DL Kerr, F Haderk, TG Bivona - Current opinion in chemical biology, 2021 - Elsevier
The nonreceptor protein tyrosine phosphatase SHP2 (encoded by PTPN11) integrates
growth and differentiation signals from receptor tyrosine kinases (RTKs) into the …

Recent advances of SHP2 inhibitors in cancer therapy: current development and clinical application

X Yuan, H Bu, J Zhou, CY Yang… - Journal of medicinal …, 2020 - ACS Publications
SHP2 (Src homology-2 domain-containing protein tyrosine phosphatase-2) is a non-
receptor protein tyrosine phosphatase that removes tyrosine phosphorylation. Functionally …

[HTML][HTML] Strategies to overcome drug resistance using SHP2 inhibitors

M Liu, S Gao, RM Elhassan, X Hou, H Fang - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Encoded by PTPN11, the SHP2 (Src homology-2 domain-containing protein tyrosine
phosphatase-2) is widely recognized as a carcinogenic phosphatase. As a promising anti …

Allosteric inhibition of SHP2: identification of a potent, selective, and orally efficacious phosphatase inhibitor

J Garcia Fortanet, CHT Chen, YNP Chen… - Journal of medicinal …, 2016 - ACS Publications
SHP2 is a nonreceptor protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene
involved in cell growth and differentiation via the MAPK signaling pathway. SHP2 also …

Identification of TNO155, an allosteric SHP2 inhibitor for the treatment of cancer

MJ LaMarche, M Acker, A Argintaru… - Journal of medicinal …, 2020 - ACS Publications
SHP2 is a nonreceptor protein tyrosine phosphatase encoded by the PTPN11 gene and is
involved in cell growth and differentiation via the MAPK signaling pathway. SHP2 also plays …

Allosteric inhibitors of SHP2 with therapeutic potential for cancer treatment

J Xie, X Si, S Gu, M Wang, J Shen, H Li… - Journal of medicinal …, 2017 - ACS Publications
SHP2, a cytoplasmic protein-tyrosine phosphatase encoded by the PTPN11 gene, is
involved in multiple cell signaling processes including Ras/MAPK and Hippo/YAP pathways …

Targeting SHP2 as a promising strategy for cancer immunotherapy

Q Liu, J Qu, M Zhao, Q Xu, Y Sun - Pharmacological research, 2020 - Elsevier
Src homology-2-containing protein tyrosine phosphatase 2 (SHP2) is a major phosphatase
involved in several cellular processes. In recent years, SHP2 has been the focus of …

Shp2: A pleiotropic target at the interface of cancer and its microenvironment

NM Sodir, G Pathria, JI Adamkewicz, EH Kelley… - Cancer discovery, 2023 - AACR
The protein phosphatase SHP2/PTPN11 has been reported to be a key modulator of
proliferative pathways in a wide range of malignancies. Intriguingly, SHP2 has also been …

[HTML][HTML] Tyrosine phosphatase SHP2 inhibitors in tumor-targeted therapies

Z Song, M Wang, Y Ge, XP Chen, Z Xu, Y Sun… - … Pharmaceutica Sinica B, 2021 - Elsevier
Src homology containing protein tyrosine phosphatase 2 (SHP2) represents a noteworthy
target for various diseases, serving as a well-known oncogenic phosphatase in cancers. As …

Optimization of fused bicyclic allosteric SHP2 inhibitors

JT Bagdanoff, Z Chen, M Acker, YN Chen… - Journal of medicinal …, 2019 - ACS Publications
SHP2 is a nonreceptor protein tyrosine phosphatase within the mitogen-activated protein
kinase (MAPK) pathway controlling cell growth, differentiation, and oncogenic …