Where the minor things are: a pan-eukaryotic survey suggests neutral processes may explain much of minor intron evolution
Spliceosomal introns are gene segments removed from RNA transcripts by
ribonucleoprotein machineries called spliceosomes. In some eukaryotes a second …
ribonucleoprotein machineries called spliceosomes. In some eukaryotes a second …
The evolution of spliceosomal introns
M Lynch, AO Richardson - Current opinion in genetics & development, 2002 - Elsevier
Although the widespread proliferation of introns in eukaryotic protein-coding genes remains
one of the most poorly understood aspects of genomic architecture, major advances have …
one of the most poorly understood aspects of genomic architecture, major advances have …
Evolutionary convergence on highly-conserved 3′ intron structures in intron-poor eukaryotes and insights into the ancestral eukaryotic genome
The presence of spliceosomal introns in eukaryotes raises a range of questions about
genomic evolution. Along with the fundamental mysteries of introns' initial proliferation and …
genomic evolution. Along with the fundamental mysteries of introns' initial proliferation and …
Origin and evolution of spliceosomal introns
Evolution of exon-intron structure of eukaryotic genes has been a matter of long-standing,
intensive debate. The introns-early concept, later rebranded 'introns first'held that protein …
intensive debate. The introns-early concept, later rebranded 'introns first'held that protein …
The spread of the first introns in proto-eukaryotic paralogs
J Vosseberg, M Schinkel, S Gremmen… - Communications biology, 2022 - nature.com
Spliceosomal introns are a unique feature of eukaryotic genes. Previous studies have
established that many introns were present in the protein-coding genes of the last eukaryotic …
established that many introns were present in the protein-coding genes of the last eukaryotic …
Worm genomes hold the smoking guns of intron gain
JM Logsdon Jr - Proceedings of the National Academy of …, 2004 - National Acad Sciences
Spliceosomal introns are prevalent in our genomes and also in our minds as unsolved
evolutionary mysteries. Are introns primordial features of eukaryotic genes? Or have they …
evolutionary mysteries. Are introns primordial features of eukaryotic genes? Or have they …
Alternative splicing: a missing piece in the puzzle of intron gain
R Tarrío, FJ Ayala… - Proceedings of the …, 2008 - National Acad Sciences
Spliceosomal introns, a hallmark of eukaryotic gene organization, were an unexpected
discovery. After three decades, crucial issues such as when and how introns first appeared …
discovery. After three decades, crucial issues such as when and how introns first appeared …
Spliceosomal introns as tools for genomic and evolutionary analysis
Over the past 5 years, the availability of dozens of whole genomic sequences from a wide
variety of eukaryotic lineages has revealed a very large amount of information about the …
variety of eukaryotic lineages has revealed a very large amount of information about the …
Origin of spliceosomal introns and alternative splicing
In this work we review the current knowledge on the prehistory, origins, and evolution of
spliceosomal introns. First, we briefly outline the major features of the different types of …
spliceosomal introns. First, we briefly outline the major features of the different types of …
The evolutionary gain of spliceosomal introns: sequence and phase preferences
WG Qiu, N Schisler, A Stoltzfus - Molecular Biology and …, 2004 - academic.oup.com
Theories regarding the evolution of spliceosomal introns differ in the extent to which the
distribution of introns reflects either a formative role in the evolution of protein-coding genes …
distribution of introns reflects either a formative role in the evolution of protein-coding genes …