ATF4-dependent transcription mediates signaling of amino acid limitation
MS Kilberg, J Shan, N Su - Trends in Endocrinology & Metabolism, 2009 - cell.com
Mammals respond to dietary nutrient fluctuations; for example, deficiency of dietary protein
or an imbalance of essential amino acids activates an amino acid response (AAR) signal …
or an imbalance of essential amino acids activates an amino acid response (AAR) signal …
[HTML][HTML] Amino acid deprivation and endoplasmic reticulum stress induce expression of multiple activating transcription factor-3 mRNA species that, when …
Transcription from the ASNS (asparagine synthetase) gene is increased in response to
either amino acid (amino acid response) or glucose (endoplasmic reticulum stress …
either amino acid (amino acid response) or glucose (endoplasmic reticulum stress …
[HTML][HTML] The transcription factor network associated with the amino acid response in mammalian cells
MS Kilberg, M Balasubramanian, L Fu, J Shan - Advances in nutrition, 2012 - Elsevier
Mammals exhibit multiple adaptive mechanisms that sense and respond to fluctuations in
dietary nutrients. Consumption of reduced total dietary protein or a protein diet that is …
dietary nutrients. Consumption of reduced total dietary protein or a protein diet that is …
Activation of the ATF3 gene through a co-ordinated amino acid-sensing response programme that controls transcriptional regulation of responsive genes following …
Expression of ATF3 (activating transcription factor 3) is induced by a variety of environmental
stress conditions, including nutrient limitation. In the present study, we demonstrate that the …
stress conditions, including nutrient limitation. In the present study, we demonstrate that the …
[PDF][PDF] ZBTB1 regulates asparagine synthesis and leukemia cell response to L-asparaginase
Summary Activating transcription factor 4 (ATF4) is a master transcriptional regulator of the
integrated stress response (ISR) that enables cell survival under nutrient stress. The …
integrated stress response (ISR) that enables cell survival under nutrient stress. The …
[HTML][HTML] Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation
J Averous, A Bruhat, C Jousse, V Carraro… - Journal of Biological …, 2004 - ASBMB
The CHOP gene is transcriptionally induced by amino acid starvation. We have previously
identified a genomic cis-acting element (amino acid response element (AARE)) involved in …
identified a genomic cis-acting element (amino acid response element (AARE)) involved in …
[HTML][HTML] ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene
F Siu, PJ Bain, R LeBlanc-Chaffin, H Chen… - Journal of Biological …, 2002 - ASBMB
Transcription from the asparagine synthetase (AS) gene is increased in response to either
amino acid (amino acid response) or glucose (endoplasmic reticulum stress response) …
amino acid (amino acid response) or glucose (endoplasmic reticulum stress response) …
Specificity of amino acid regulated gene expression: analysis of genes subjected to either complete or single amino acid deprivation
SS Palii, CE Kays, C Deval, A Bruhat, P Fafournoux… - Amino acids, 2009 - Springer
Amino acid deprivation activates the amino acid response (AAR) pathway that enhances
transcription of genes containing an amino acid response element (AARE). The present data …
transcription of genes containing an amino acid response element (AARE). The present data …
[HTML][HTML] Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis
X Tang, MM Keenan, J Wu, CA Lin, L Dubois… - PLoS …, 2015 - journals.plos.org
Besides being building blocks for protein synthesis, amino acids serve a wide variety of
cellular functions, including acting as metabolic intermediates for ATP generation and for …
cellular functions, including acting as metabolic intermediates for ATP generation and for …
Amino Acids Control Mammalian Gene Transcription: Activating Transcription Factor 2 Is Essential for the Amino Acid Responsiveness of the CHOP Promoter
A Bruhat, C Jousse, V Carraro… - … and cellular biology, 2000 - Taylor & Francis
In mammals, plasma concentration of amino acids is affected by nutritional or pathological
conditions. It has been well established that nutrients, and particularly amino acids, are …
conditions. It has been well established that nutrients, and particularly amino acids, are …