Perineuronal nets (PNNs) were shown to be markedly altered in subjects with
schizophrenia. In particular, decreases of PNNs have been detected in the amygdala …

Schizophrenia is a complex brain disorder associated with deficits in synaptic connectivity.
The insidious onset of this illness during late adolescence and early adulthood has been …

Background Perineuronal nets (PNNs) are extracellular matrix structures that enwrap many
neurons in the brain. They regulate the postnatal experience-dependent maturation of brain …

Rapidly emerging evidence implicates perineuronal nets (PNNs) and extracellular matrix
(ECM) molecules that compose or interact with PNNs, in the pathophysiology of several …

The neural extracellular matrix (ECM) plays an important role in regulation of perisomatic
GABAergic inhibition and synaptic plasticity in the hippocampus and cortex. Decreased …

Background Alterations in the structure and physiology of interneurons in the prefrontal
cortex (PFC) are important factors in the etiopathology of different psychiatric disorders …

Both early life aversive experiences and intrinsic alterations in early postnatal
neurodevelopment are considered predisposing factors for psychiatric disorders, such as …

Perineuronal nets (PNNs) in the brain are condensed glycosaminoglycan-rich extracellular
matrix structures with heterogeneous composition yet specific organization. They typically …

Perineuronal nets (PNNs) are specialized extracellular matrix aggregates surrounding
distinct neuronal populations and regulating synaptic functions and plasticity. Previous …

Perineuronal nets (PNNs) are highly organized components of the extracellular matrix that
surround a subset of mature neurons in the CNS. These structures play a critical role in …