Metals and mechanisms of carcinogenesis

QY Chen, T DesMarais, M Costa - Annual review of …, 2019 - annualreviews.org
Metal exposure is pervasive and not limited to sporadic poisoning events or toxic waste
sites. Hundreds of millions of people around the globe are affected by chronic metal …

Metals and molecular carcinogenesis

Y Zhu, M Costa - Carcinogenesis, 2020 - academic.oup.com
Many metals are essential for living organisms, but at higher doses they may be toxic and
carcinogenic. Metal exposure occurs mainly in occupational settings and environmental …

Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms

D Beyersmann, A Hartwig - Archives of toxicology, 2008 - Springer
Mechanisms of carcinogenicity are discussed for metals and their compounds, classified as
carcinogenic to humans or considered to be carcinogenic to humans: arsenic, antimony …

Epigenetic regulation in chromium-, nickel-and cadmium-induced carcinogenesis

L Zhao, R Islam, Y Wang, X Zhang, LZ Liu - Cancers, 2022 - mdpi.com
Simple Summary Environmental and occupational exposure to heavy metals are risk factors
for cancers. However, the molecular mechanisms of how heavy metals induce …

Toxicological principles of metal carcinogenesis with special emphasis on cadmium

MP Waalkes, TP Coogan, RA Barter - Critical reviews in toxicology, 1992 - Taylor & Francis
Metals are an important and emerging class of carcinogens. At least three metals,
specifically nickel, chromium, and arsenic, are confirmed human carcinogens, and several …

Metal-induced carcinogenesis, oxidative stress and hypoxia signalling

A Galanis, A Karapetsas, R Sandaltzopoulos - Mutation research/Genetic …, 2009 - Elsevier
Heavy metal-induced carcinogenesis is well documented by epidemiological studies.
Several diverse mechanisms of cancer induction may be involved, depending on the form of …

Metal carcinogenesis: mechanistic implications

ET Snow - Pharmacology & therapeutics, 1992 - Elsevier
Cancer epidemiology has identified several metal compounds as human carcinogens.
Recent evidence suggests that carcinogenic metals induce genotoxicity in a multiplicity of …

Signaling by carcinogenic metals and metal-induced reactive oxygen species

GK Harris, X Shi - … Research/Fundamental and Molecular Mechanisms of …, 2003 - Elsevier
Epidemiological data indicate that exposure to metal and metalloid species, including
arsenic (III), chromium (VI), and nickel (II), increases the risk of cancer, particularly of the …

Mechanisms in cadmium-induced carcinogenicity: recent insights

A Hartwig - Biometals, 2010 - Springer
Cadmium is an environmental pollutant, with relevant exposures at workplaces and in the
general population. The carcinogenicity has been long established, most evident for tumors …

Metal ions in human cancer development

EJ Tokar, L Benbrahim-Tallaa - 2010 - books.rsc.org
Metals have been in the environment during the entire evolution of man and the use of
metals is key to human civilization. None-the-less, several very toxic species are included in …