Cancer-associated fibrosis is a critical component of the tumor microenvironment (TME)
which significantly impacts cancer behavior. However, there is significant controversy …

In malignant tumors, cancer cells adapt to grow within their host tissue. As a cancer
progresses, an accompanying host stromal response evolves within and around the nascent …

Simple Summary Stroma modifications observed in solid cancer are now recognized as
critical events for cancer progression and as potential therapeutic or diagnostic targets. The …

Cumulative evidence shows that fibrogenic stroma and stiff extracellular matrix (ECM) not
only result from tumor growth but also play pivotal roles in cellular transformation and tumor …

Simple Summary The tumor microenvironment plays an important role in determining the
biological behavior of several of the more aggressive malignancies. Among the various cell …

Tumor cells reside in a highly complex and heterogeneous tumor microenvironment (TME),
which is composed of a myriad of genetically stable non-cancer cells, including fibroblasts …

The major cellular components of tumor microenvironment, referred to as the cancer stroma,
are composed of cancer-associated fibroblasts that support tumor epithelial growth, invasion …

The extracellular matrix (ECM) plays an important role in cancer progression. It can be
divided into the basement membrane (BM) that supports epithelial/endothelial cell behavior …

Tumorigenesis is a complex process involving dynamic interactions between malignant cells
and their surrounding stroma, including both the cellular and acellular components. Within …

Reciprocal interactions between tumor and stromal cells propel cancer progression and
metastasis. A complete understanding of the complex contributions of the tumor stroma to …