In the past few years, it has become clear that mutations in epigenetic regulatory genes are
common in human cancers. Therapeutic strategies are now being developed to target …

Epigenetic dysregulation is a common feature of most cancers, often occurring directly
through alteration of epigenetic machinery. Over the last several years, a new generation of …

The initiation and progression of cancer is controlled by both genetic and epigenetic events.
Unlike genetic alterations, which are almost impossible to reverse, epigenetic aberrations …

Any alteration at the genetic or epigenetic level, may result in multiplex of diseases including
tumorigenesis which ultimately results in the cancer development. Restoration of the normal …

Epigenetic gene silencing is a hallmark of cancer cells. Two important types of epigenetic
changes are DNA methylation and histone modification. These modifications are catalysed …

The appropriate coordination between epigenetic regulators is essential for spatial and
temporal regulation of gene expression and maintenance of cell identity. Cancer is a …

Cancer can be identified as a chaotic cell state, which breaks the rules that govern growth
and reproduction, with main characteristics such as uncontrolled division, invading other …

The past 15 years have seen an explosion of discoveries related to the cellular regulation of
phenotypes through epigenetic mechanisms. This regulation provides a software that …

Epigenetic drug discovery field has evidenced significant advancement in the recent times.
A plethora of small molecule inhibitors have progressed to clinical stage investigations and …

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