Redesigning of cell-penetrating peptides to improve their efficacy as a drug delivery system
Cell-penetrating peptides (CPP) are promising tools for the transport of a broad range of
compounds into cells. Since the discovery of the first members of this peptide family, many …
compounds into cells. Since the discovery of the first members of this peptide family, many …
Cationic and amphipathic cell-penetrating peptides (CPPs): Their structures and in vivo studies in drug delivery
Over the past few decades, cell penetrating peptides (CPPs) have become an important
class of drug carriers for small molecules, proteins, genes and nanoparticle systems. CPPs …
class of drug carriers for small molecules, proteins, genes and nanoparticle systems. CPPs …
Twenty years of cell‐penetrating peptides: from molecular mechanisms to therapeutics
F Heitz, MC Morris, G Divita - British journal of pharmacology, 2009 - Wiley Online Library
The recent discovery of new potent therapeutic molecules that do not reach the clinic due to
poor delivery and low bioavailability have made of delivery a key stone in therapeutic …
poor delivery and low bioavailability have made of delivery a key stone in therapeutic …
[PDF][PDF] Effects of Tryptophan Content and Backbone Spacing on Uptake Efficiency of Cell-Penetrating Peptides
HA Rydberg, M Matson, HL Åmand, EK Esbjörner… - Biophysical …, 2012 - cell.com
Cell-penetrating peptides (CPPs) have recently gained considerable interest due to their
ability to cross cellular membranes and deliver macromolecular cargo. It is of great …
ability to cross cellular membranes and deliver macromolecular cargo. It is of great …
Cell penetrating peptides: intracellular pathways and pharmaceutical perspectives
Cell penetrating peptides, generally categorized as amphipathic or cationic depending on
their sequence, are increasingly drawing attention as a non-invasive delivery technology for …
their sequence, are increasingly drawing attention as a non-invasive delivery technology for …
Chemical-functional diversity in cell-penetrating peptides
S Stalmans, E Wynendaele, N Bracke, B Gevaert… - PloS one, 2013 - journals.plos.org
Cell-penetrating peptides (CPPs) are a promising tool to overcome cell membrane barriers.
They have already been successfully applied as carriers for several problematic cargoes …
They have already been successfully applied as carriers for several problematic cargoes …
Cell-penetrating peptides: A comparative study on lipid affinity and cargo delivery properties
P Ruzza, B Biondi, A Marchiani, N Antolini, A Calderan - Pharmaceuticals, 2010 - mdpi.com
A growing number of natural and/or synthetic peptides with cell membrane penetrating
capability have been identified and described in the past years. These molecules have been …
capability have been identified and described in the past years. These molecules have been …
Internalization mechanisms of cell-penetrating peptides
I Ruseska, A Zimmer - Beilstein journal of nanotechnology, 2020 - beilstein-journals.org
In today's modern era of medicine, macromolecular compounds such as proteins, peptides
and nucleic acids are dethroning small molecules as leading therapeutics. Given their …
and nucleic acids are dethroning small molecules as leading therapeutics. Given their …
Challenge to overcome current limitations of cell-penetrating peptides
The penetration of biological membranes is a prime obstacle for the delivery of
pharmaceutical drugs. Cell-penetrating peptide (CPP) is an efficient vehicle that can deliver …
pharmaceutical drugs. Cell-penetrating peptide (CPP) is an efficient vehicle that can deliver …
Recent advances of studies on cell-penetrating peptides based on molecular dynamics simulations
J Ouyang, Y Sheng, W Wang - Cells, 2022 - mdpi.com
With the ability to transport cargo molecules across cell membranes with low toxicity, cell-
penetrating peptides (CPPs) have become promising candidates for next generation peptide …
penetrating peptides (CPPs) have become promising candidates for next generation peptide …