Redesigning of cell-penetrating peptides to improve their efficacy as a drug delivery system

I Szabó, M Yousef, D Soltész, C Bató, G Mező… - Pharmaceutics, 2022 - mdpi.com
Cell-penetrating peptides (CPP) are promising tools for the transport of a broad range of
compounds into cells. Since the discovery of the first members of this peptide family, many …

Cationic and amphipathic cell-penetrating peptides (CPPs): Their structures and in vivo studies in drug delivery

JL Zaro, WC Shen - Frontiers of Chemical Science and Engineering, 2015 - Springer
Over the past few decades, cell penetrating peptides (CPPs) have become an important
class of drug carriers for small molecules, proteins, genes and nanoparticle systems. CPPs …

Twenty years of cell‐penetrating peptides: from molecular mechanisms to therapeutics

F Heitz, MC Morris, G Divita - British journal of pharmacology, 2009 - Wiley Online Library
The recent discovery of new potent therapeutic molecules that do not reach the clinic due to
poor delivery and low bioavailability have made of delivery a key stone in therapeutic …

[PDF][PDF] Effects of Tryptophan Content and Backbone Spacing on Uptake Efficiency of Cell-Penetrating Peptides

HA Rydberg, M Matson, HL Åmand, EK Esbjörner… - Biophysical …, 2012 - cell.com
Cell-penetrating peptides (CPPs) have recently gained considerable interest due to their
ability to cross cellular membranes and deliver macromolecular cargo. It is of great …

Cell penetrating peptides: intracellular pathways and pharmaceutical perspectives

LN Patel, JL Zaro, WC Shen - Pharmaceutical research, 2007 - Springer
Cell penetrating peptides, generally categorized as amphipathic or cationic depending on
their sequence, are increasingly drawing attention as a non-invasive delivery technology for …

Chemical-functional diversity in cell-penetrating peptides

S Stalmans, E Wynendaele, N Bracke, B Gevaert… - PloS one, 2013 - journals.plos.org
Cell-penetrating peptides (CPPs) are a promising tool to overcome cell membrane barriers.
They have already been successfully applied as carriers for several problematic cargoes …

Cell-penetrating peptides: A comparative study on lipid affinity and cargo delivery properties

P Ruzza, B Biondi, A Marchiani, N Antolini, A Calderan - Pharmaceuticals, 2010 - mdpi.com
A growing number of natural and/or synthetic peptides with cell membrane penetrating
capability have been identified and described in the past years. These molecules have been …

Internalization mechanisms of cell-penetrating peptides

I Ruseska, A Zimmer - Beilstein journal of nanotechnology, 2020 - beilstein-journals.org
In today's modern era of medicine, macromolecular compounds such as proteins, peptides
and nucleic acids are dethroning small molecules as leading therapeutics. Given their …

Challenge to overcome current limitations of cell-penetrating peptides

GC Kim, DH Cheon, Y Lee - Biochimica et Biophysica Acta (BBA)-Proteins …, 2021 - Elsevier
The penetration of biological membranes is a prime obstacle for the delivery of
pharmaceutical drugs. Cell-penetrating peptide (CPP) is an efficient vehicle that can deliver …

Recent advances of studies on cell-penetrating peptides based on molecular dynamics simulations

J Ouyang, Y Sheng, W Wang - Cells, 2022 - mdpi.com
With the ability to transport cargo molecules across cell membranes with low toxicity, cell-
penetrating peptides (CPPs) have become promising candidates for next generation peptide …