[HTML][HTML] EMAST is a form of microsatellite instability that is initiated by inflammation and modulates colorectal cancer progression

JM Carethers, M Koi, SS Tseng-Rogenski - Genes, 2015 - mdpi.com
DNA mismatch repair (MMR) function is critical for correcting errors coincident with
polymerase-driven DNA replication, and its proteins are frequent targets for inactivation …

Microsatellite instability pathway and EMAST in colorectal cancer

JM Carethers - Current colorectal cancer reports, 2017 - Springer
Microsatellite instability (MSI) refers to the biochemical detection of frameshifted
microsatellite sequences from genomic DNA. Genesis of MSI is due to defective DNA …

Relationship of EMAST and microsatellite instability among patients with rectal cancer

B Devaraj, A Lee, BL Cabrera, K Miyai, L Luo… - Journal of …, 2010 - Elsevier
Background Elevated microsatellite instability at selected tetranucleotide repeats (EMAST) is
a genetic signature identified in 60% of sporadic colon cancers and may be linked with …

Combined microsatellite instability and elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) might be a more promising immune biomarker …

MH Chen, SC Chang, PC Lin, SH Yang, CC Lin… - The …, 2019 - academic.oup.com
Background The form of microsatellite instability (MSI) affecting tetranucleotide repeats
known as elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) …

Genetic instability caused by loss of MutS homologue 3 in human colorectal cancer

AC Haugen, A Goel, K Yamada, G Marra, TP Nguyen… - Cancer research, 2008 - AACR
Microsatellite instability (MSI) is a hallmark of mismatch repair (MMR) deficiency. High levels
of MSI at mononucleotide and dinucleotide repeats in colorectal cancer (CRC) are attributed …

[HTML][HTML] MSH3-deficiency initiates EMAST without oncogenic transformation of human colon epithelial cells

C Campregher, G Schmid, F Ferk, S Knasmüller… - PloS one, 2012 - journals.plos.org
Background/Aim Elevated microsatellite instability at selected tetranucleotide repeats
(EMAST) is a genetic signature in certain cases of sporadic colorectal cancer and has been …

[HTML][HTML] Oxidative stress induces nuclear-to-cytosol shift of hMSH3, a potential mechanism for EMAST in colorectal cancer cells

SS Tseng-Rogenski, H Chung, MB Wilk, S Zhang… - PloS one, 2012 - journals.plos.org
Background Elevated microsatellite alterations at selected tetranucleotide repeats (EMAST)
is a genetic signature observed in 60% of sporadic colorectal cancers (CRCs). Unlike …

Microsatellite alterations at selected tetranucleotide repeats are associated with morphologies of colorectal neoplasias

SY Lee, H Chung, B Devaraj, M Iwaizumi, HS Han… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS:: Elevated microsatellite alterations at selected tetranucleotide
repeats (EMAST) occurs during microsatellite instability (MSI) that is not associated with …

Microsatellite instability in colorectal cancer: from molecular oncogenic mechanisms to clinical implications

A Zaanan, K Meunier, F Sangar, JF Fléjou, F Praz - Cellular oncology, 2011 - Springer
Background Microsatellite instability (MSI) constitutes an important oncogenic molecular
pathway in colorectal cancer (CRC), representing approximately 15% of all colorectal …

Elevated microsatellite alterations at selected tetranucleotides in early‐stage colorectal cancers with and without high‐frequency microsatellite instability: Same, same …

MM Watson, D Lea, E Rewcastle, HR Hagland… - Cancer …, 2016 - Wiley Online Library
Microsatellite instability (MSI) is associated with better prognosis in colorectal cancer (CRC).
Elevated microsatellite alterations at selected tetranucleotides (EMAST) is a less …