Non-viral gene delivery vectors are emerging as a safer alternative to viral vectors. Among
natural polymers, chitosan (Ch) is the most studied one, and low molecular weight Ch …

In the last few decades, there has been a growing interest towards the use of delivery
systems for a more effective treatment of various diseases and the research increasingly …

The ideal gene polyplexes should have a subtle balance between polyplex stability to
protect DNA against nucleases, and polyplex instability to permit DNA dissociation inside …

Purpose. Studies on DNA complexes with cationic polymers are prompted by the search for
nonviral DNA carriers for gene therapy. Among them, poly (L-Lysine)(PLL) has been …

Non-viral gene delivery vectors have lagged far behind viral ones in the current pipeline of
clinical trials of gene therapy nanomedicines. Even when non-viral nanovectors pose less …

Gene therapy holds immense potential as a future therapeutic strategy for the treatment of
numerous genetic diseases which are incurable to date. Nevertheless, safe and efficient …

Purpose. Chitosan, a natural cationic polysaccharide, is a candidate non-viral vector for
gene delivery. With the aim of developing this system, various biophysical characteristics of …

Alternatives to efficient viral vectors in gene therapy are desired because of their poor safety
profiles. Chitosan is a promising non-viral nucleotide delivery vector because of its …

The aim of this study is to investigate the effects of molecular weight, the pyridinium/trimethyl
ammonium (Py/Tr) ratio, the nitrogen atoms (N) in the methylated N-(3-pyridylmethyl) …

Chitosan, trimethyl chitosan or polyethylenglycol-graft-trimethyl chitosan/DNA complexes
were characterized concerning physicochemical properties such as hydrodynamic diameter …