Aims To determine the role played by adenosine, ATP and chemoreflex activation on the
regulation of vascular conductance in chronic hypoxia. Methods The vascular conductance …

Introduction Adenosine is an ATP derivative that is strongly implicated in the cardiovascular
adaptive response to exercise. In this study, we hypothesized that during exercise the …

We tested the hypothesis that adenosine contributes to augmented skeletal muscle
vasodilation during hypoxic exercise. In separate protocols, subjects performed incremental …

In humans, hypoxia leads to increased sympathetic neural outflow to skeletal muscle.
However, blood flow increases in the forearm. The mechanism of hypoxia-induced …

Hypoxic pulmonary vasoconstriction may limit aerobic exercise capacity at high altitude by
two different mechanisms, which both affect the convectional transport of oxygen to the …

Background—Adenosine is a potent vasodilator that has been shown to increase in cardiac
tissue in response to hypoxia. However, peripheral vasodilatation also occurs during …

To test the hypothesis that the increased sympathetic tonus elicited by chronic hypoxia is
needed to match O2 delivery with O2 demand at the microvascular level eight male subjects …

Background In chronic hypoxia, both heart rate (HR) and cardiac output (Q) are reduced
during exercise. The role of parasympathetic neural activity in lowering HR is unresolved …

Abstract Matthias Peter Hilty, Andrea Mueller, Daniela Flück, Christoph Siebenmann, Peter
Rasmussen, Stefanie Keiser, Katja Auinger, Carsten Lundby, and Marco Maggiorini. Effect …

1 In anaesthetised rats, the increase in femoral vascular conductance (FVC) evoked by
moderate systemic hypoxia is mediated by adenosine acting on A1 receptors. It is also nitric …