Abstract Toll-like receptor 4 (TLR4), a member of the Toll-like receptor (TLR) family, is
involved in innate immunity and mediates inflammatory responses by recognizing …

Toll-like receptor 4 (TLR4), together with MD-2, binds bacterial endotoxins (E) with high
affinity, triggering formation of the activated homodimer (E. MD-2. TLR4) 2. Activated TLR4 …

Many inflammatory diseases may be linked to pathologically elevated signaling via the
receptor for lipopolysaccharide (LPS), toll-like receptor 4 (TLR4). There has thus been great …

Activation or inhibition of TLR4 by small molecules will provide in the next few years a new
generation of therapeutics. TLR4 stimulation (agonism) by high-affinity ligands mimicking …

Abstract Toll-like receptor 4 (TLR4) is expressed in a wide variety of cells and is the central
component of the mammalian innate immune system. Since its discovery in 1997, TLR4 has …

Toll-like receptor 4 (TLR4), along with its accessory protein myeloid differentiation factor 2
(MD-2), builds a heterodimeric complex that specifically recognizes lipopolysaccharides …

Toll-Like Receptor 4 (TLR4) signal pathway plays an important role in initiating the innate
immune response and its activation by bacterial endotoxin is responsible for chronic and …

Early recognition of invading bacteria by the innate immune system has a crucial function in
antibacterial defense by triggering inflammatory responses that prevent the spread of …

The Toll‐like receptor (TLR) family acts as a bridge connecting innate and acquired
immunity. TLR10 remains one of the least understood members of this family. Some studies …

Conspectus Toll-like receptors (TLRs) are the “gatekeepers” of the immune system in
humans and other animals to protect the host from invading bacteria, viruses, and other …