Abstract mTORC2 phosphorylates AKT in a hydrophobic motif site that is a biomarker of
insulin sensitivity. In brown adipocytes, mTORC2 regulates glucose and lipid metabolism …

Summary mTORC2 controls glucose and lipid metabolism, but the mechanisms are unclear.
Here, we show that conditionally deleting the essential mTORC2 subunit Rictor in murine …

Background The signaling pathways imposing hormonal control over adipocyte
differentiation are poorly understood. While insulin and Akt signaling have been found …

Deregulation of mTOR complex 1 (mTORC1) signalling increases the risk for metabolic
diseases, including type 2 diabetes. Here we show that β-cell-specific loss of mTORC1 …

A classic metabolic concept posits that insulin promotes energy storage and adipose
expansion, while catecholamines stimulate release of adipose energy stores by hydrolysis …

Objective Normal adipose tissue growth and function is critical to maintaining metabolic
homeostasis and its excess (eg obesity) or absence (eg lipodystrophy) is associated with …

Acetylation is increasingly recognized as one of the major post-translational mechanisms for
the regulation of multiple cellular functions in mammalian cells. Acetyltransferase p300 …

Highly proliferating cells are particularly dependent on glucose and glutamine for
bioenergetics and macromolecule biosynthesis. The signals that respond to nutrient …

Beige adipocytes are present in white adipose tissue (WAT) and have thermogenic capacity
to orchestrate substantial energy metabolism and counteract obesity. However, adipocyte …

The coactivator‐associated arginine methyltransferase 1 (CARM1) is recruited to gene
promoters by many transcription factors. To identify new pathways that use CARM1, we …