The rate of action potential firing in nociceptors is a major determinant of the intensity of
pain. Possible modulators of action potential firing include the HCN ion channels, which …

Peripheral pain pathways are activated by a range of stimuli. We used diphtheria toxin to kill
all mouse postmitotic sensory neurons expressing the sodium channel Nav1. 8. Mice …

Acute nociceptive pain is caused by the direct action of a noxious stimulus on pain-sensitive
nerve endings, whereas inflammatory pain (both acute and chronic) arises from the actions …

Inflammation, trauma, or nerve injury may cause enduring hyperalgesia, an enhanced
sensitivity to painful stimuli. Neurons in lamina I of the spinal dorsal horn that express the …

The capsaicin (vanilloid) receptor VR1 is a cation channel expressed by primary sensory
neurons of the “pain” pathway. Heterologously expressed VR1 can be activated by vanilloid …

Sensory acuity and motor dexterity deteriorate when human limbs cool down, but pain
perception persists and cold-induced pain can become excruciating. Evolutionary pressure …

Neuropathic pain is a common and often incapacitating clinical problem for which little
useful therapy is presently available. Painful peripheral neuropathies can have many …

In normal animals, peripheral nerve injury produces a persistent, neuropathic pain state in
which pain is exaggerated and can be produced by nonpainful stimuli. Here, mice that lack …

This study establishes a mechanism for metabolic hyperalgesia based on the glycolytic
metabolite methylglyoxal. We found that concentrations of plasma methylglyoxal above 600 …

Neuropathic pain arises as a debilitating consequence of nerve injury. The etiology of such
pain is poorly understood, and existing treatment is largely ineffective. We demonstrate here …