Cardiomyocyte maturation during pre-and postnatal development requires multiple
intertwined processes, including a switch in energy generation from glucose utilization in the …

Myocardial tissue homeostasis is critically important for heart development, growth and
function throughout the life course. The loss of cardiomyocytes under pathological …

Mitochondria are essential for the development as well as maintenance of the myocardium,
the most energy consuming tissue in the human body. Mitochondria are not only a source of …

Whereas adult cardiomyocytes are highly susceptible to stress, cardiomyocytes in the
prenatal heart appear to be rather resistant. To investigate how embryonic cardiomyocytes …

Fetal cardiomyocyte adaptation to low levels of oxygen in utero is incompletely understood,
and is of interest as hypoxia tolerance is lost after birth, leading to vulnerability of adult …

Cardiac energy metabolism must cope with early postnatal changes in tissue oxygen
tensions, hemodynamics, and cell proliferation to sustain development. Here, we tested the …

The mammalian heart has a remarkable regenerative capacity for a short period of time after
birth, after which the majority of cardiomyocytes permanently exit cell cycle. We sought to …

Alterations in energy metabolism play a major role in the lineage of cardiomyocytes, such as
the dramatic changes that occur in the transition from neonate to newborn. As …

Newborn mammalian cardiomyocytes quickly transition from a fetal to an adult phenotype
that utilizes mitochondrial oxidative phosphorylation but loses mitotic capacity. We tested …

Continuous developmental maturation of cardiomyocytes is essential to meet the functional
and metabolic demands of the growing heart. A new study (Hom et al., 2011) reports that …