Pathway for the biosynthesis of the pigment chrysogine by Penicillium chrysogenum

A Viggiano, O Salo, H Ali, W Szymanski… - Applied and …, 2018 - Am Soc Microbiol
Chrysogine is a yellow pigment produced by Penicillium chrysogenum and other
filamentous fungi. Although the pigment was first isolated in 1973, its biosynthetic pathway …

Chrysogine biosynthesis is mediated by a two-module nonribosomal peptide synthetase

RD Wollenberg, W Saei, KR Westphal… - Journal of natural …, 2017 - ACS Publications
Production of chrysogine has been reported from several fungal genera including
Penicillium, Aspergillus, and Fusarium. Anthranilic acid and pyruvic acid, which are …

[HTML][HTML] Penicillium chrysogenum, a Vintage Model with a Cutting-Edge Profile in Biotechnology

F Fierro, I Vaca, NI Castillo, RO García-Rico, R Chávez - Microorganisms, 2022 - mdpi.com
The discovery of penicillin entailed a decisive breakthrough in medicine. No other medical
advance has ever had the same impact in the clinical practise. The fungus Penicillium …

Identification of the main regulator responsible for synthesis of the typical yellow pigment produced by Trichoderma reesei

C Derntl, A Rassinger, E Srebotnik… - Applied and …, 2016 - Am Soc Microbiol
The industrially used ascomycete Trichoderma reesei secretes a typical yellow pigment
during cultivation, while other Trichoderma species do not. A comparative genomic analysis …

[HTML][HTML] Genomic mutational analysis of the impact of the classical strain improvement program on β–lactam producing Penicillium chrysogenum

OV Salo, M Ries, MH Medema, PP Lankhorst… - BMC genomics, 2015 - Springer
Background Penicillium chrysogenum is a filamentous fungus that is employed as an
industrial producer of β–lactams. The high β–lactam titers of current strains is the result of a …

The global regulator LaeA controls penicillin biosynthesis, pigmentation and sporulation, but not roquefortine C synthesis in Penicillium chrysogenum

K Kosalková, C García-Estrada, RV Ullán, RP Godio… - Biochimie, 2009 - Elsevier
The biosynthesis of the β-lactam antibiotic penicillin is an excellent model for the study of
secondary metabolites produced by filamentous fungi due to the good background …

[HTML][HTML] A Branched Biosynthetic Pathway Is Involved in Production of Roquefortine and Related Compounds in Penicillium chrysogenum

H Ali, MI Ries, JG Nijland, PP Lankhorst… - PloS one, 2013 - journals.plos.org
Profiling and structural elucidation of secondary metabolites produced by the filamentous
fungus Penicillium chrysogenum and derived deletion strains were used to identify the …

Identification of a polyketide synthase involved in sorbicillin biosynthesis by Penicillium chrysogenum

O Salo, F Guzmán-Chávez, MI Ries… - Applied and …, 2016 - Am Soc Microbiol
Secondary metabolism in Penicillium chrysogenum was intensively subjected to classical
strain improvement (CSI), the resulting industrial strains producing high levels of β-lactams …

Biosynthetic concepts for the production of β‐lactam antibiotics in Penicillium chrysogenum

SS Weber, RAL Bovenberg… - Biotechnology …, 2012 - Wiley Online Library
Industrial production of β‐lactam antibiotics by the filamentous fungus Penicillium
chrysogenum is based on successive classical strain improvement cycles. This review …

[HTML][HTML] Novel key metabolites reveal further branching of the roquefortine/meleagrin biosynthetic pathway

MI Ries, H Ali, PP Lankhorst, T Hankemeier… - Journal of Biological …, 2013 - ASBMB
Metabolic profiling and structural elucidation of novel secondary metabolites obtained from
derived deletion strains of the filamentous fungus Penicillium chrysogenum were used to …