Reflections on the use of 10 IARC carcinogenic characteristics for an objective approach to identifying and organizing results from certain mechanistic studies
JE Trosko - Toxicology Research and Application, 2017 - journals.sagepub.com
To find a scientifically based method for evaluating mechanistic data related to risks to
human beings, a new protocol for identifying, organizing, and summarizing mechanistic data …
human beings, a new protocol for identifying, organizing, and summarizing mechanistic data …
IARC classes 1 and 2 carcinogens are successfully identified by an alternative strategy that detects DNA-reactivity and cell transformation ability of chemicals
R Benigni, C Bossa, CL Battistelli… - … /Genetic Toxicology and …, 2013 - Elsevier
For decades, traditional toxicology has been the ultimate source of information on the
carcinogenic potential of chemicals; however with increasing demand on regulation of …
carcinogenic potential of chemicals; however with increasing demand on regulation of …
Ten years of using key characteristics of human carcinogens to organize and evaluate mechanistic evidence in IARC Monographs on the identification of carcinogenic …
Systematic review and evaluation of mechanistic evidence using the Key Characteristics
approach was proposed by the International Agency for Research on Cancer (IARC) in 2012 …
approach was proposed by the International Agency for Research on Cancer (IARC) in 2012 …
[PDF][PDF] Analysis of key characteristics of human carcinogens
D Krewski, M Al-Zoughool, M Bird, N Birkett, M Billard… - 2019 - ora.ox.ac.uk
Since its establishment in the early 1970s, the IARC Monographs Programme has evaluated
more than 1000 agents with evidence of human exposure and for which some suspicion …
more than 1000 agents with evidence of human exposure and for which some suspicion …
Use of mechanistic data in IARC evaluations
VJ Cogliano, RA Baan, K Straif… - Environmental and …, 2008 - Wiley Online Library
Consideration of mechanistic data has the potential to improve the analysis of both
epidemiologic studies and cancer bioassays. IARC has a classification system in which …
epidemiologic studies and cancer bioassays. IARC has a classification system in which …
Classification of chemicals for carcinogenic and mutagenic properties
PGN Kramers, H Roelfzema - Toxicology letters, 1992 - Elsevier
In the framework of the EC labelling guide, three categories were devised for carcinogenic
as well as for mutagenic chemicals. In short, category 1 is for compounds shown to produce …
as well as for mutagenic chemicals. In short, category 1 is for compounds shown to produce …
Tumour site concordance and mechanisms of carcinogenesis
RA Baan, BW Stewart, K Straif - 2019 - pubmed.ncbi.nlm.nih.gov
This Scientific Publication reviews the information on cancer sites and mechanistic events
for the more than 100 agents classified in Group 1 (carcinogenic to humans) by the IARC …
for the more than 100 agents classified in Group 1 (carcinogenic to humans) by the IARC …
Chemicals classified by IARC: their potency in tests for carcinogenicity in rodents and their genotoxicity and acute toxicity.
DB McGregor - IARC Scientific Publications, 1992 - europepmc.org
Chemicals classified by the IARC to its groups 1, 2A, 2B and 3 were examined in an attempt
to identify characteristics of their behaviour in experimental studies of carcinogenicity …
to identify characteristics of their behaviour in experimental studies of carcinogenicity …
Key characteristics of 86 agents known to cause cancer in humans
D Krewski, M Bird, M Al-Zoughool, N Birkett… - Journal of Toxicology …, 2019 - Taylor & Francis
Since the inception of the International Agency for Research on Cancer (IARC) in the early
1970s, the IARC Monographs Programme has evaluated more than 1000 agents with …
1970s, the IARC Monographs Programme has evaluated more than 1000 agents with …
Use of Carcinogenicity Bioassays in the IARC Monographs
VJ Cogliano - Annals of the New York Academy of Sciences, 2006 - Wiley Online Library
Carcinogenicity bioassays generally provide the best means of assessing the potential for a
chemical to be a human carcinogenic hazard. The results of carcinogenicity bioassays are …
chemical to be a human carcinogenic hazard. The results of carcinogenicity bioassays are …