[HTML][HTML] Myogenic regulatory transcription factors regulate growth in rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is a pediatric malignacy of muscle with myogenic regulatory
transcription factors MYOD and MYF5 being expressed in this disease. Consensus in the …
transcription factors MYOD and MYF5 being expressed in this disease. Consensus in the …
[HTML][HTML] SIX1 reprograms myogenic transcription factors to maintain the rhabdomyosarcoma undifferentiated state
JY Hsu, EP Danis, S Nance, JH O'Brien, AL Gustafson… - Cell reports, 2022 - cell.com
Rhabdomyosarcoma (RMS) is a pediatric muscle sarcoma characterized by expression of
the myogenic lineage transcription factors (TFs) MYOD1 and MYOG. Despite high …
the myogenic lineage transcription factors (TFs) MYOD1 and MYOG. Despite high …
Dysregulated myogenesis in rhabdomyosarcoma
YY Peter, DC Guttridge - Current Topics in Developmental Biology, 2018 - Elsevier
Rhabdomyosarcoma is a mesenchymal malignancy associated with the skeletal muscle
lineage and is also the most common pediatric soft tissue cancer. Between the two pediatric …
lineage and is also the most common pediatric soft tissue cancer. Between the two pediatric …
Muscle regulatory factor MRF4 activates differentiation in rhabdomyosarcoma RD cells through a positive-acting C-terminal protein domain
V Sirri, MP Leibovitch, SA Leibovitch - Oncogene, 2003 - nature.com
Rhabdomyosarcoma (RMS) has deregulated proliferation and is blocked in the
differentiation program despite Myf-5, MyoD and myogenin expression. Here we show that …
differentiation program despite Myf-5, MyoD and myogenin expression. Here we show that …
[HTML][HTML] CASZ1 induces skeletal muscle and rhabdomyosarcoma differentiation through a feed-forward loop with MYOD and MYOG
Z Liu, X Zhang, H Lei, N Lam, S Carter… - Nature …, 2020 - nature.com
Embryonal rhabdomyosarcoma (ERMS) is a childhood cancer that expresses myogenic
master regulatory factor MYOD but fails to differentiate. Here, we show that the zinc finger …
master regulatory factor MYOD but fails to differentiate. Here, we show that the zinc finger …
Comparison of genome-wide binding of MyoD in normal human myogenic cells and rhabdomyosarcomas identifies regional and local suppression of promyogenic …
Rhabdomyosarcoma is a pediatric tumor of skeletal muscle that expresses the myogenic
basic helix-loop-helix protein MyoD but fails to undergo terminal differentiation. Prior work …
basic helix-loop-helix protein MyoD but fails to undergo terminal differentiation. Prior work …
Identification of new genes related to the myogenic differentiation arrest of human rhabdomyosarcoma cells
A Astolfi, C De Giovanni, L Landuzzi, G Nicoletti… - Gene, 2001 - Elsevier
Rhabdomyosarcoma is a soft tissue tumor committed to the myogenic lineage but arrested
prior to terminal differentiation. To identify new genes implicated in the block in myogenic …
prior to terminal differentiation. To identify new genes implicated in the block in myogenic …
[HTML][HTML] miR-206 integrates multiple components of differentiation pathways to control the transition from growth to differentiation in rhabdomyosarcoma cells
Background Similar to replicating myoblasts, many rhabdomyosarcoma cells express the
myogenic determination gene MyoD. In contrast to myoblasts, rhabdomyosarcoma cells do …
myogenic determination gene MyoD. In contrast to myoblasts, rhabdomyosarcoma cells do …
Rhabdomyosarcoma–working out the pathways
G Merlino, LJ Helman - Oncogene, 1999 - nature.com
Rhabdomyosarcomas constitute a collection of childhood malignancies thought to arise as a
consequence of regulatory disruption of skeletal muscle progenitor cell growth and …
consequence of regulatory disruption of skeletal muscle progenitor cell growth and …
[HTML][HTML] Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma
S Pomella, P Sreenivas, BE Gryder, L Wang… - Nature …, 2021 - nature.com
Rhabdomyosarcoma (RMS) is an aggressive pediatric malignancy of the muscle, that
includes Fusion Positive (FP)-RMS harboring PAX3/7-FOXO1 and Fusion Negative (FN) …
includes Fusion Positive (FP)-RMS harboring PAX3/7-FOXO1 and Fusion Negative (FN) …