The dual role of 20 (S)-protopanaxadiol in alleviating pulmonary fibrosis through the gut-lung axis

Y Ruan, G Ren, M Wang, W Lv, K Shimizu, C Zhang - Phytomedicine, 2024 - Elsevier
Abstract Background Pulmonary Fibrosis (PF) is a progressive lung disease characterized
by the diffuse interstitial tissue, leading to severe breathing difficulties. The existing treatment …

[HTML][HTML] Ginseng saponin metabolite 20 (S)-protopanaxadiol relieves pulmonary fibrosis by multiple-targets signaling pathways

G Ren, W Lv, Y Ding, L Wang, ZG Cui, R Li… - Journal of Ginseng …, 2023 - Elsevier
Abstract Background Panax ginseng Meyer is a representative Chinese herbal medicine
with antioxidant and anti-inflammatory activity. 20 (S)-Protopanaxadiol (PPD) has been …

[HTML][HTML] Polyphyllin B inhibited STAT3/NCOA4 pathway and restored gut microbiota to ameliorate lung tissue injury in cigarette smoke-induced mice

Q Wang, Z He, J Zhu, M Hu, L Yang, H Yang - BMC biotechnology, 2024 - Springer
Objective Smoking was a major risk factor for chronic obstructive pulmonary disease
(COPD). This study plan to explore the mechanism of Polyphyllin B in lung injury induced by …

Mechanistic investigation of xuebijing for treatment of paraquat-induced pulmonary fibrosis by metabolomics and network pharmacology

T Wang, S Li, Y Wu, X Yan, Y Zhu, Y Jiang, F Jiang… - ACS …, 2021 - ACS Publications
After paraquat (PQ) poisoning, it is difficult to accurately diagnose patients' condition by only
measuring their blood PQ concentration. Therefore, it is important to establish an accurate …

[HTML][HTML] Inhalation of panaxadiol alleviates lung inflammation via inhibiting TNFA/TNFAR and IL7/IL7R signaling between macrophages and epithelial cells

Y Wang, H Wei, Z Song, L Jiang, M Zhang, X Lu… - Journal of Ginseng …, 2024 - Elsevier
Background Lung inflammation occurs in many lung diseases, but has limited effective
therapeutics. Ginseng and its derivatives have anti-inflammatory effects, but their unstable …

Integrated proteomics and metabolomics reveal variations in pulmonary fibrosis development and the potential therapeutic effect of Shuangshen Pingfei formula

Y Chen, X Li, X Fan - Journal of Ethnopharmacology, 2023 - Elsevier
Abstract Ethnopharmacological relevance Shuangshen Pingfei formula (SSPF), a Chinese
medicine prescription, has been prescribed to alleviate PF. However, little is known about …

Integrating metabolomics and network pharmacology analysis to explore mechanism of Pueraria lobata against pulmonary fibrosis: Involvement of arginine …

H Du, M Shao, S Xu, Q Yang, J Xu, H Ke, L Zou… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Pueraria lobata (Willd.) Ohwi is a typical
medicinal and edible plant with a long application history in China and Southeast Asia. As a …

[HTML][HTML] Integration of metabolomics and network pharmacology to reveal the protective mechanism underlying Qibai Pingfei capsule on chronic obstructive …

J Xie, M Liu, Y Gao, C Liu, F Wu, J Tong, Z Li… - Frontiers in …, 2023 - frontiersin.org
In this study, we have employed metabolomics technology in combination with network
pharmacology to ascertain the key metabolites and hub genes. The objective was to explore …

[HTML][HTML] Bu-Fei-Huo-Xue capsule alleviates bleomycin-induced pulmonary fibrosis in mice through modulating gut microbiota

H Hu, F Wang, P Han, P Li, K Wang, H Song… - Frontiers in …, 2023 - frontiersin.org
Introduction: Bu-Fei-Huo-Xue capsule (BFHX) has been used to treat pulmonary fibrosis
(PF) in clinic. However, the mechanism of Bu-Fei-Huo-Xue capsule on pulmonary fibrosis …

Regulation effect of the intestinal flora and intervention strategies targeting the intestinal flora in alleviation of pulmonary fibrosis development

J GUO, L YANG - Bioscience of Microbiota, Food and Health, 2024 - jstage.jst.go.jp
Pulmonary fibrosis is an end-stage respiratory disease characterized by fibroblast
proliferation and accumulation of extracellular matrix and collagen, which is accompanied …