Antitumor activity of linear, β-cyclodextrin polymer (CDP)− camptothecin (CPT) conjugates
(HGGG6, LGGG10, HG6, and HGGG10) is investigated in nude mice bearing human …

6A, 6D-Bis-(2-amino-2-carboxylethylthio)-6A, 6D-dideoxy-β-cyclodextrin 1, a diamino acid
derivative of β-cyclodextrin, is synthesized and condensed with difunctionalized PEG …

The solubility of camptothecin (CPT), a highly potent antineoplastic agent, as a function of
different concentrations of cyclodextrins (α-cyclodextrin, α-CD; β-cyclodextrin, β-CD; and γ …

Purpose: IT-101 is a camptothecin–polymer conjugate prepared by linking camptothecin
(CPT) to a hydrophilic, cyclodextrin-based, linear polymer through ester bonds. In previous …

IT-101 (Insert Therapeutics-101) is a linear, cyclodextrin-containing polymer conjugate of
camptothecin (CPT). When formulated properly, the polymer conjugate self-assembles into …

Clinically available camptothecins (CPTs), such as irinotecan (CPT-11) and topotecan,
represent one of the most promising classes of antitumor agents, despite their toxicity. To …

Conclusion The pharmacokinetics of DX-8951f were greatly improved by DE-310 with the
extremely longer retention in bloodstream, resulting in the preferential tumor-targeting, and …

A water soluble macromolecular conjugate of camptothecin (CPT) with a new, dual phase
hydrolytic drug release mechanism was prepared on the basis of a 60 kDa biodegradable …

Camptothecin showed remarkable anticancer activity in animal models of cancer but was
restricted in clinical use for its adverse toxicity in patients. The preclinical efficacy of …

Camptothecin (CPT), a plant alkaloid, is a potent anticancer drug in cell culture studies but it
is clinically inactive due to rapid hydrolysis under physiological conditions. The drug exists …