In this review, we discuss the functions and main effects on pregnancy outcomes of three
agents that have the ability to induce epigenetic modifications: valproic acid (VPA), a well …

S-adenosylmethionine (SAMe) is involved in many transmethylation reactions in most living
organisms and is also required in the synthesis of several substances such as monoamine …

Valproic acid (VPA) is a very effective anticonvulsant and mood stabilizer with relatively few
side effects. Being an epigenetic modulator, it undergoes clinical trials for the treatment of …

Chemically induced birth defects are an important public health and human problem. Here
we use Xenopus and zebrafish as models to investigate the mechanism of action of a well …

Exposure to the anticonvulsant drug valproic acid (VPA) in utero is associated with a 1–2%
increase in neural tube defects (NTDs), however the molecular mechanisms by which VPA …

Gestational exposure to the anticonvulsant drug valproic acid (VPA) is associated with
congenital malformations and neurodevelopmental disorders through its action as a histone …

Valproic acid (VPA) is a known human teratogen. Exposure in pregnancy is associated with
approximately three-fold increase in the rate of major anomalies, mainly spina bifida and …

An estimated 60 million people worldwide suffer from epilepsy, half of whom are women.
About one-third of women with epilepsy are of childbearing age. The childbirth rate in …

Introduction Valproic acid (VPA), a widely prescribed antiepileptic drug and an effective
treatment for bipolar disorder and neuropathic pain, results in multiple developmental …

The risks associated with in utero antiepileptic drug (AED) exposure are of great importance
for both epileptic women and their offspring. This review considers the basic mechanisms of …