Importance E-cadherin (CDH1) is a cancer predisposition gene mutated in families meeting
clinically defined hereditary diffuse gastric cancer (HDGC). Reliable estimates of cancer risk …

Gastric cancer ranks as the third leading cause of cancer mortality worldwide and confers a
5-year survival of 20%. While most gastric cancers are sporadic,~ 1%–3% can be attributed …

BACKGROUND. A subset of patients with diffuse gastric cancer harbor deleterious cancer‐
causing germline mutations in the type 1 E‐cadherin (epithelial) gene (CDH1), which …

Importance Inherited variants in the tumor suppressor geneCDH1are associated with an
increased risk of gastric and breast cancers. This review aims to address the most current …

Background Hereditary diffuse gastric cancer (HDGC) is a familial cancer syndrome
specifically associated with germline mutations to the E-cadherin (CDH1) gene. HDGC is …

Hereditary diffuse gastric cancer (HDGC) is the only known cancer syndrome that is
dominated by gastric adenocarcinoma. HDGC is caused by germline mutation of the CDH1 …

BACKGROUND & AIMS:: Germline mutations in CDH1 are known to cause hereditary
diffuse gastric cancer (HDGC). Breast and colorectal cancer have also been reported in …

ContextHereditary diffuse gastric cancer is caused by germline mutations in the epithelial
cadherin (CDH1) gene and is characterized by an increased risk for diffuse gastric cancer …

Background & Aims Germline mutations in the cadherin 1, type 1, E-cadherin gene (CDH1)
cause a predisposition to gastric cancer. We evaluated the ability of the internationally …

Background: Mutations in the E-cadherin (CDH1) gene are a well documented cause of
hereditary diffuse gastric cancer (HDGC). Development of evidence based guidelines for …