Background To address the major methodological issues of reverse causation and selection
bias in epidemiologic studies of antibiotic use in early life and the development of asthma …

Many studies have reported that antibiotic use may be associated with increased risk of
childhood asthma. Respiratory tract infections in small children may be difficult to distinguish …

BACKGROUND. Antibiotic exposure in early childhood is a possible contributor to the
increasing asthma prevalence in industrialized countries. Although a number of published …

Background The use of antibiotic therapy early in life might influence the risk of developing
asthma. Studies assessing the influence of early life antibiotic use on the risk of asthma …

Background An association between antibiotic use in early life and asthma in childhood has
been reported in five retrospective studies and one longitudinal study. Objective To examine …

Objectives To determine the association between antibiotic exposure in the first year of life
and the development of childhood asthma. Design Metaanalysis of observational studies …

Five retrospective studies have reported an association between antibiotic use in early life
and asthma in childhood. We studied the relationship between the use of oral antibiotics in …

Background Asthma prevalence has doubled in developed countries during the past 30
years. Pre-and perinatal events are essential in shaping the development of the immune …

Background A recent study suggested that early‐life intestinal microbiota may play an
important role in the development of childhood asthma, indicating that antibiotics taken …

Background Antibiotic use in infancy disrupts gut microflora during a critical period for
immune system development. It is hypothesized that this could predispose to the …