Metabotyping of human colorectal cancer using two-dimensional gas chromatography mass spectrometry

M Mal, PK Koh, PY Cheah, ECY Chan - Analytical and bioanalytical …, 2012 - Springer
Colorectal cancer (CRC) is the fourth most common cause of death from cancer in the world.
The limitations of the currently available methods and biomarkers for CRC management …

Application of ethyl chloroformate derivatization for gas chromatography–mass spectrometry based metabonomic profiling

Y Qiu, M Su, Y Liu, M Chen, J Gu, J Zhang, W Jia - Analytica chimica acta, 2007 - Elsevier
A new combined gas chromatography and mass spectrometry (GC–MS) method has been
developed suitable for the urine sample treatment in aqueous phase with ethyl …

Metabonomics identifies serum metabolite markers of colorectal cancer

B Tan, Y Qiu, X Zou, T Chen, G Xie… - Journal of proteome …, 2013 - ACS Publications
Recent studies suggest that biofluid-based metabonomics may identify metabolite markers
promising for colorectal cancer (CRC) diagnosis. We report here a follow-up replication …

¹H NMR-based metabolic profiling of human rectal cancer tissue

H Wang, L Wang, H Zhang, P Deng, J Chen, B Zhou… - Molecular cancer, 2013 - Springer
Background Rectal cancer is one of the most prevalent tumor types. Understanding the
metabolic profile of rectal cancer is important for developing therapeutic approaches and …

Tissue metabonomic phenotyping for diagnosis and prognosis of human colorectal cancer

Y Tian, T Xu, J Huang, L Zhang, S Xu, B Xiong… - Scientific reports, 2016 - nature.com
Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide
and prognosis based on the conventional histological grading method for CRC remains …

[HTML][HTML] A gas chromatography-mass spectrometry (GC-MS) metabolomic approach in human colorectal cancer (CRC): the emerging role of monosaccharides and …

L Barberini, A Restivo, A Noto, S Deidda… - Annals of …, 2019 - ncbi.nlm.nih.gov
Background Colorectal cancer (CRC) has been confirmed to be the third most commonly
diagnosed cancer in males and the second in females. We investigated the blood plasma …

Development and validation of a gas chromatography/mass spectrometry method for the metabolic profiling of human colon tissue

M Mal, PK Koh, PY Cheah… - … Communications in Mass …, 2009 - Wiley Online Library
In this study, a gas chromatography/mass spectrometry (GC/MS) method was developed
and validated for the metabolic profiling of human colon tissue. Each colon tissue sample …

Study of metabonomic profiles of human esophageal carcinoma by use of high-resolution magic-angle spinning 1H NMR spectroscopy and multivariate data analysis

Y Yang, L Wang, S Wang, S Liang, A Chen… - Analytical and …, 2013 - Springer
Esophageal carcinoma (EC) is one of the most common malignant tumors. EC survival has
remained disappointingly low because of the high malignancy of esophageal cancer and …

Comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry for metabonomics: Biomarker discovery for diabetes mellitus

X Li, Z Xu, X Lu, X Yang, P Yin, H Kong, Y Yu… - Analytica Chimica Acta, 2009 - Elsevier
Comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry
(GC× GC–TOFMS) coupled with pattern recognition methods was applied to analyze plasma …

[HTML][HTML] Optimizing 2D gas chromatography mass spectrometry for robust tissue, serum and urine metabolite profiling

Z Yu, H Huang, A Reim, PD Charles, A Northage… - Talanta, 2017 - Elsevier
Two-dimensional gas chromatography mass spectrometry (GCxGC-MS) is utilized to an
increasing extent in biomedical metabolomics. Here, we established and adapted …