Protein kinase CK2–diverse roles in cancer cell biology and therapeutic promise

JH Trembley, BT Kren, M Afzal, GA Scaria… - Molecular and cellular …, 2023 - Springer
The association of protein kinase CK2 (formerly casein kinase II or 2) with cell growth and
proliferation in cells was apparent at early stages of its investigation. A cancer-specific role …

Protein kinase CK2 in health and disease: CK2: a key player in cancer biology

JH Trembley, G Wang, G Unger, J Slaton… - Cellular and molecular …, 2009 - Springer
Elevated levels of protein kinase CK2 (formerly casein kinase 2 or II) have long been
associated with increased cell growth and proliferation both in normal and cancer cells. The …

Emergence of protein kinase CK2 as a key target in cancer therapy

JH Trembley, Z Chen, G Unger, J Slaton, BT Kren… - Biofactors, 2010 - Wiley Online Library
Protein kinase CK2, a protein serine/threonine kinase, plays a global role in activities related
to cell growth, cell death, and cell survival. CK2 has a large number of potential substrates …

Protein kinase CK2 and cancer: further clues are accumulating

O Filhol, C Cochet - Bulletin du Cancer, 2002 - jle.com
Protein kinase CK2 appears to interact with different signaling pathways and therefore
represents the prototype of a multifunctional protein kinase. The enzyme is highly expressed …

Protein kinase CK2 as regulator of cell survival: implications for cancer therapy

GM Unger, AT Davis, JW Slaton… - Current cancer drug …, 2004 - ingentaconnect.com
Recent studies have generated sufficient information to warrant a consideration of protein
kinase CK2 as a potential target for cancer therapy. CK2 is a ubiquitous and highly …

Protein kinase CK2 cellular function in normal and disease states

K Ahmed, OG Issinger, R Szyszka - 2015 - Springer
The selection of “Protein Kinase CK2 Cellular Function in Normal and Disease State,” as
part of the Springer series “Advances in Biochemistry in Health and Disease”(Volume 12) …

Too much of a good thing: the role of protein kinase CK2 in tumorigenesis and prospects for therapeutic inhibition of CK2

JS Duncan, DW Litchfield - Biochimica et Biophysica Acta (BBA)-Proteins …, 2008 - Elsevier
CK2 is a highly conserved protein serine/threonine kinase that is ubiquitously distributed in
eukaryotes, constitutively active and has been implicated in multiple cellular functions, as …

Protein kinase CK2–a key suppressor of apoptosis

KA Ahmad, G Wang, G Unger, J Slaton… - Advances in enzyme …, 2008 - Elsevier
In recent years, evidence has mounted in support of the importance of protein kinase CK2
(previously called casein kinase 2 or II)(EC 2.7. 11.1) in diverse biological processes, and …

Protein kinase CK2 is a constitutively active enzyme that promotes cell survival: strategies to identify CK2 substrates and manipulate its activity in mammalian cells

JP Turowec, JS Duncan, AC French, L Gyenis… - Methods in …, 2010 - Elsevier
Protein kinase CK2 is a constitutively active protein serine/threonine kinase that is
ubiquitously expressed and essential for the survival of eukaryotic cells. On the basis of its …

Validation of protein kinase CK2 as oncological target

S Seeber, OG Issinger, T Holm, LP Kristensen… - Apoptosis, 2005 - Springer
Protein kinase CK2 is a highly conserved enzyme composed of two catalytic subunits α
and/or α′ and two regulatory subunits β whose activity is elevated in diverse tumour types …