Protein kinase CK2–diverse roles in cancer cell biology and therapeutic promise
JH Trembley, BT Kren, M Afzal, GA Scaria… - Molecular and cellular …, 2023 - Springer
The association of protein kinase CK2 (formerly casein kinase II or 2) with cell growth and
proliferation in cells was apparent at early stages of its investigation. A cancer-specific role …
proliferation in cells was apparent at early stages of its investigation. A cancer-specific role …
Protein kinase CK2 in health and disease: CK2: a key player in cancer biology
JH Trembley, G Wang, G Unger, J Slaton… - Cellular and molecular …, 2009 - Springer
Elevated levels of protein kinase CK2 (formerly casein kinase 2 or II) have long been
associated with increased cell growth and proliferation both in normal and cancer cells. The …
associated with increased cell growth and proliferation both in normal and cancer cells. The …
Emergence of protein kinase CK2 as a key target in cancer therapy
JH Trembley, Z Chen, G Unger, J Slaton, BT Kren… - Biofactors, 2010 - Wiley Online Library
Protein kinase CK2, a protein serine/threonine kinase, plays a global role in activities related
to cell growth, cell death, and cell survival. CK2 has a large number of potential substrates …
to cell growth, cell death, and cell survival. CK2 has a large number of potential substrates …
Protein kinase CK2 and cancer: further clues are accumulating
O Filhol, C Cochet - Bulletin du Cancer, 2002 - jle.com
Protein kinase CK2 appears to interact with different signaling pathways and therefore
represents the prototype of a multifunctional protein kinase. The enzyme is highly expressed …
represents the prototype of a multifunctional protein kinase. The enzyme is highly expressed …
Protein kinase CK2 as regulator of cell survival: implications for cancer therapy
GM Unger, AT Davis, JW Slaton… - Current cancer drug …, 2004 - ingentaconnect.com
Recent studies have generated sufficient information to warrant a consideration of protein
kinase CK2 as a potential target for cancer therapy. CK2 is a ubiquitous and highly …
kinase CK2 as a potential target for cancer therapy. CK2 is a ubiquitous and highly …
Protein kinase CK2 cellular function in normal and disease states
The selection of “Protein Kinase CK2 Cellular Function in Normal and Disease State,” as
part of the Springer series “Advances in Biochemistry in Health and Disease”(Volume 12) …
part of the Springer series “Advances in Biochemistry in Health and Disease”(Volume 12) …
Too much of a good thing: the role of protein kinase CK2 in tumorigenesis and prospects for therapeutic inhibition of CK2
JS Duncan, DW Litchfield - Biochimica et Biophysica Acta (BBA)-Proteins …, 2008 - Elsevier
CK2 is a highly conserved protein serine/threonine kinase that is ubiquitously distributed in
eukaryotes, constitutively active and has been implicated in multiple cellular functions, as …
eukaryotes, constitutively active and has been implicated in multiple cellular functions, as …
Protein kinase CK2–a key suppressor of apoptosis
In recent years, evidence has mounted in support of the importance of protein kinase CK2
(previously called casein kinase 2 or II)(EC 2.7. 11.1) in diverse biological processes, and …
(previously called casein kinase 2 or II)(EC 2.7. 11.1) in diverse biological processes, and …
Protein kinase CK2 is a constitutively active enzyme that promotes cell survival: strategies to identify CK2 substrates and manipulate its activity in mammalian cells
JP Turowec, JS Duncan, AC French, L Gyenis… - Methods in …, 2010 - Elsevier
Protein kinase CK2 is a constitutively active protein serine/threonine kinase that is
ubiquitously expressed and essential for the survival of eukaryotic cells. On the basis of its …
ubiquitously expressed and essential for the survival of eukaryotic cells. On the basis of its …
Validation of protein kinase CK2 as oncological target
S Seeber, OG Issinger, T Holm, LP Kristensen… - Apoptosis, 2005 - Springer
Protein kinase CK2 is a highly conserved enzyme composed of two catalytic subunits α
and/or α′ and two regulatory subunits β whose activity is elevated in diverse tumour types …
and/or α′ and two regulatory subunits β whose activity is elevated in diverse tumour types …