Introduction Because only a small portion of NSCLC (non-small-cell lung cancer) patients
benefit from molecular targeted therapy or immunotherapy and do not develop therapeutic …

Background: SEROTONIN (5HT) has been shown to be a mitogenic factor in several
carcinomas. Its mitogenic effect is elicited through a wide range of 5HT receptor subtypes. In …

Purpose Psychological stress is a crucial driver of tumorigenesis and cancer metastasis. The
impact of the stress-associated neurotransmitter 5-hydroxytryptamine (5-HT) on tumor …

The 5-HT1A receptor is a pharmacologically well characterized serotonin receptor subtype
and it has long been investigated because of its involvement in several physiopathological …

Prostate cancer (PCa) is one of the most common types of cancer seen among men
worldwide. Previous studies have demonstrated that serotonin regulates cell proliferation …

Purpose There is lack of evidence about impact of 5-HT receptors on colorectal cancers. The
current study was designed to investigate the role of serotonin and its receptors in colorectal …

Abstract Overexpression of 5-hydroxytryptamine (5-HT) in human cancer contributes to
tumor metastasis, but the role of 5-HT receptor family in cancer has not been thoroughly …

hydroxytryptamine receptor 3A (HTR3A) is an important member of the 5‑HT family, which
has been suggested to contribute to human tumor development. However, the functions of …

Lung cancer is the leading cause of cancer death around the world. Adenocarcinoma is the
most common histological type and has various histologic subtypes: lepidic, acinar …

Background Laryngeal cancer is a common malignancy of the head and neck, it's important
to find novel targets for its therapy. The 5-hydroxytryptamine receptor 7 (HTR7) belongs to …