Although nicotinic receptors have been demonstrated in hypothalamic appetite-regulating
areas and nicotine administration alters food intake and body weight in both animals and …

Appetite is regulated by a number of hypothalamic neuropeptides including neuropeptide Y
(NPY), a powerful feeding stimulator that responds to feeding status, and drugs such as …

Epidemiological studies have shown an inverse relationship between cigarette smoking and
body weight. In rodents, a negative correlation between nicotine and body weight has been …

Nicotine is known to decrease body weight in normal rodents and human smokers, whereas
nicotine withdrawal or smoking cessation can increase body weight. We have found that …

Obesity and cigarette smoking are both important risk factors for insulin resistance,
cardiovascular disease, and cancer. Smoking reduces appetite, which makes many people …

Although numerous epidemiological studies have provided convincing evidence for the
inverse association between tobacco smoking and body weight, the molecular mechanisms …

Rationale: Despite irrefutable epidemiologic evidence, cigarette smoking remains the major
preventable cause of lung disease morbidity worldwide. The appetite-suppressing effect of …

The appetite suppressing effect of tobacco is a major driver of smoking behaviour; however
few studies have addressed the effects of chronic cigarette smoke exposure (SE) on …

Neuropeptide Y (NPY) is synthesized in arcuate (ARC) neurons which project principally to
the paraventricular nucleus (PVN). NPY injected into the PVN causes hyperphagia, reduced …

Chronic tobacco use leads to nicotine addiction that is characterized by exaggerated urges
to use the drug despite the accompanying negative health and socioeconomic burdens …