PPARγ signaling in hepatocarcinogenesis: mechanistic insights for cellular reprogramming and therapeutic implications

SM Ishtiaq, MI Arshad, JA Khan - Pharmacology & Therapeutics, 2022 - Elsevier
Liver cancer or hepatocellular carcinoma (HCC) is leading cause of cancer-related
mortalities globally. The therapeutic approaches for chronic liver diseases-associated liver …

PPAR could contribute to the pathogenesis of hepatocellular carcinoma

O Kimura, Y Kondo, T Shimosegawa - PPAR research, 2012 - Wiley Online Library
Viral hepatitis with hepatitis C virus or hepatitis B virus and chronic liver disease such as
alcoholic or nonalcoholic steatohepatitis are critical factors in the development of …

[HTML][HTML] Peroxisome proliferator-activated receptor gamma as a therapeutic target for hepatocellular carcinoma: Experimental and clinical scenarios

S Katoch, V Sharma, V Patial - World Journal of Gastroenterology, 2022 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is the most common type of liver cancer worldwide. Viral
hepatitis is a significant risk factor for HCC, although metabolic syndrome and diabetes are …

Ligand-activated PPARδ expression promotes hepatocellular carcinoma progression by regulating the PI3K-AKT signaling pathway

W Han, N Wang, R Kong, W Bao, J Lu - Journal of Translational Medicine, 2022 - Springer
Background Peroxisome proliferator-activated receptor-beta/delta (PPARδ) was considered
as the key regulator involved in the evolution of various tumors. Given that PPARδ potential …

[HTML][HTML] Peroxisome proliferator activated receptor alpha inhibits hepatocarcinogenesis through mediating NF-κB signaling pathway

N Zhang, ESH Chu, J Zhang, X Li, Q Liang, J Chen… - Oncotarget, 2014 - ncbi.nlm.nih.gov
Peroxisome proliferator-activated receptor alpha (PPARα) ligands have been reported to
suppress cancer growth. However, the role of PPARα in hepatocarcinogenesis remains …

The role of PPARγ in hepatocellular carcinoma

I Borbath, Y Horsmans - PPAR research, 2008 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the third leading cause of cancer‐related death
worldwide. This cancer develops mainly in cirrhotic patients. The cirrhotic liver is considered …

Emerging role of the peroxisome proliferator-activated receptor-gamma in hepatocellular carcinoma

HT Hsu, CW Chi - Journal of hepatocellular carcinoma, 2014 - Taylor & Francis
Hepatocellular carcinoma (HCC) is the major leading cause of cancer death worldwide.
Hepatitis B virus, hepatitis C virus, alcohol consumption, non-alcoholic fatty liver disease …

Transcriptomic signatures of peroxisome proliferator-activated receptor α (PPARα) in different mouse liver models identify novel aspects of its biology

E Szalowska, HA Tesfay, SAFT van Hijum, S Kersten - BMC genomics, 2014 - Springer
Background The peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-
activated transcription factor that regulates lipid catabolism and inflammation and is …

Functional role of peroxisome‐proliferator‐activated receptor γ in hepatocellular carcinoma

CW Wu, GC Farrell, J Yu - Journal of gastroenterology and …, 2012 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Major risk
factors of HCC include infection with hepatitis B or C viruses, alcohol and non‐alcoholic fatty …

[PDF][PDF] Inhibitory role of peroxisome proliferator‐activated receptor gamma in hepatocarcinogenesis in mice and in vitro

J Yu, BO Shen, ESH Chu, N Teoh, KF Cheung… - …, 2010 - Wiley Online Library
Although peroxisome proliferator‐activated receptor gamma (PPARγ) agonist have been
shown to inhibit hepatocellular carcinoma (HCC) development, the role of PPARγ in …