PPARγ signaling in hepatocarcinogenesis: mechanistic insights for cellular reprogramming and therapeutic implications
SM Ishtiaq, MI Arshad, JA Khan - Pharmacology & Therapeutics, 2022 - Elsevier
Liver cancer or hepatocellular carcinoma (HCC) is leading cause of cancer-related
mortalities globally. The therapeutic approaches for chronic liver diseases-associated liver …
mortalities globally. The therapeutic approaches for chronic liver diseases-associated liver …
PPAR could contribute to the pathogenesis of hepatocellular carcinoma
O Kimura, Y Kondo, T Shimosegawa - PPAR research, 2012 - Wiley Online Library
Viral hepatitis with hepatitis C virus or hepatitis B virus and chronic liver disease such as
alcoholic or nonalcoholic steatohepatitis are critical factors in the development of …
alcoholic or nonalcoholic steatohepatitis are critical factors in the development of …
[HTML][HTML] Peroxisome proliferator-activated receptor gamma as a therapeutic target for hepatocellular carcinoma: Experimental and clinical scenarios
Hepatocellular carcinoma (HCC) is the most common type of liver cancer worldwide. Viral
hepatitis is a significant risk factor for HCC, although metabolic syndrome and diabetes are …
hepatitis is a significant risk factor for HCC, although metabolic syndrome and diabetes are …
Ligand-activated PPARδ expression promotes hepatocellular carcinoma progression by regulating the PI3K-AKT signaling pathway
W Han, N Wang, R Kong, W Bao, J Lu - Journal of Translational Medicine, 2022 - Springer
Background Peroxisome proliferator-activated receptor-beta/delta (PPARδ) was considered
as the key regulator involved in the evolution of various tumors. Given that PPARδ potential …
as the key regulator involved in the evolution of various tumors. Given that PPARδ potential …
[HTML][HTML] Peroxisome proliferator activated receptor alpha inhibits hepatocarcinogenesis through mediating NF-κB signaling pathway
Peroxisome proliferator-activated receptor alpha (PPARα) ligands have been reported to
suppress cancer growth. However, the role of PPARα in hepatocarcinogenesis remains …
suppress cancer growth. However, the role of PPARα in hepatocarcinogenesis remains …
The role of PPARγ in hepatocellular carcinoma
I Borbath, Y Horsmans - PPAR research, 2008 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the third leading cause of cancer‐related death
worldwide. This cancer develops mainly in cirrhotic patients. The cirrhotic liver is considered …
worldwide. This cancer develops mainly in cirrhotic patients. The cirrhotic liver is considered …
Emerging role of the peroxisome proliferator-activated receptor-gamma in hepatocellular carcinoma
HT Hsu, CW Chi - Journal of hepatocellular carcinoma, 2014 - Taylor & Francis
Hepatocellular carcinoma (HCC) is the major leading cause of cancer death worldwide.
Hepatitis B virus, hepatitis C virus, alcohol consumption, non-alcoholic fatty liver disease …
Hepatitis B virus, hepatitis C virus, alcohol consumption, non-alcoholic fatty liver disease …
Transcriptomic signatures of peroxisome proliferator-activated receptor α (PPARα) in different mouse liver models identify novel aspects of its biology
Background The peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-
activated transcription factor that regulates lipid catabolism and inflammation and is …
activated transcription factor that regulates lipid catabolism and inflammation and is …
Functional role of peroxisome‐proliferator‐activated receptor γ in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Major risk
factors of HCC include infection with hepatitis B or C viruses, alcohol and non‐alcoholic fatty …
factors of HCC include infection with hepatitis B or C viruses, alcohol and non‐alcoholic fatty …
[PDF][PDF] Inhibitory role of peroxisome proliferator‐activated receptor gamma in hepatocarcinogenesis in mice and in vitro
J Yu, BO Shen, ESH Chu, N Teoh, KF Cheung… - …, 2010 - Wiley Online Library
Although peroxisome proliferator‐activated receptor gamma (PPARγ) agonist have been
shown to inhibit hepatocellular carcinoma (HCC) development, the role of PPARγ in …
shown to inhibit hepatocellular carcinoma (HCC) development, the role of PPARγ in …