Purinergic signalling, consisting of extracellular purines and purinergic receptors, modulates
cell proliferation, invasion and immunological reaction during cancer progression. Here, we …

Cancer is a complex disease with a rapid growing incidence and often characterized by a
poor prognosis. Although impressive advances have been made in cancer treatments …

Purines were long thought to be restricted to the intracellular compartment, where they are
used for energy transactions, nucleic acid synthesis, and a multiplicity of biochemical …

Virtually, all tumor cells as well as all immune cells express plasma membrane receptors for
extracellular nucleosides (adenosine) and nucleotides (ATP, ADP, UTP, UDP and sugar …

Regardless of improved biological insights and therapeutic advances, cancer is consuming
multiple lives worldwide. Cancer is a complex disease with diverse cellular, metabolic, and …

Cancer comprises a collection of diseases that occur in almost any tissue and it is
characterized by an abnormal and uncontrolled cell growth that results in tumor formation …

Highlights What are the main findings? CD39-CD73 axis in tumor-associated immune cells
promotes immune exhaustion, impairment of antitumor immune activity, and increased CRC …

Receptors for extracellular nucleotides are widely expressed by mammalian cells. They
mediate a large array of responses ranging from growth stimulation to apoptosis, from …

Nucleotides and nucleosides have emerged as important modulators of tumor biology.
Recently acquired evidence shows that, when these molecules are released by cancer cells …

Gastric cancer (GC) is a major health concern worldwide, presenting a complex
pathophysiology that has hindered many therapeutic efforts so far. In this context, purinergic …