microRNAs in cardiovascular disease: small molecules but big roles

B Yan, H Wang, Y Tan, W Fu - Current topics in medicinal …, 2019 - ingentaconnect.com
microRNAs (miRNAs) are an evolutionarily conserved class of small single-stranded
noncoding RNAs. The aberrant expression of specific miRNAs has been implicated in the …

The role of microRNA in the development, diagnosis, and treatment of cardiovascular disease: recent developments

A Wronska - Journal of Pharmacology and Experimental …, 2023 - ASPET
Since their discovery in 1993, microRNAs (miRNAs) have emerged as important regulators
of many crucial cellular processes, and their dysregulation have been shown to contribute to …

MicroRNA-based therapeutics in cardiovascular disease: screening and delivery to the target

D Mellis, A Caporali - Biochemical Society Transactions, 2018 - portlandpress.com
MicroRNAs (miRNAs) are small non-coding RNAs of∼ 22 nucleotides, which have
increasingly been recognized as potent post-transcriptional regulators of gene expression …

MicroRNA‐based therapeutic approaches in the cardiovascular system

J Fiedler, SK Gupta, T Thum - Cardiovascular Therapeutics, 2012 - Wiley Online Library
MicroRNAs (miRNAs) are endogenous small ribonucleotides that participate in the
orchestration of the genome by regulating target messenger RNA translation. MiRNAs …

MicroRNA therapeutics in cardiovascular medicine

T Thum - EMBO molecular medicine, 2012 - embopress.org
Cardiovascular diseases are the most common causes of human morbidity and mortality
despite significant therapeutic improvements by surgical, interventional and …

The emerging role of microRNAs as a therapeutic target for cardiovascular disease

HY Seok, DZ Wang - BioDrugs, 2010 - Springer
MicroRNAs (miRNAs) are a class of small non-coding RNAs that are endogenously
transcribed and processed into∼ 21-to∼ 23-nucleotide products. They are believed to …

MicroRNAs as candidate drug targets for cardiovascular diseases

P Hang, J Guo, C Sun, Z Du - Current drug targets, 2017 - ingentaconnect.com
MicroRNAs (miRNAs) are small conserved noncoding RNAs which function as
posttranscriptional regulators of gene expression. Studies over the last 20 years have …

MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles

E Van Rooij, EN Olson - Nature reviews Drug discovery, 2012 - nature.com
In recent years, prominent roles for microRNAs (miRNAs) have been uncovered in several
cardiovascular disorders. The ability to therapeutically manipulate miRNA expression and …

Small things matter: relevance of microRNAs in cardiovascular disease

LJF Peters, EAL Biessen, M Hohl, C Weber… - Frontiers in …, 2020 - frontiersin.org
MicroRNAs (miRNAs) are short sequences of non-coding RNA that play an important role in
the regulation of gene expression and thereby in many physiological and pathological …

Therapeutic advances in MicroRNA targeting

RL Montgomery, E van Rooij - Journal of cardiovascular …, 2011 - journals.lww.com
In the last 10 years it has become increasingly clear that a large class of small noncoding
RNAs, known as microRNAs (miRNAs) are potent and crucial regulators of important cellular …